Soft tissue sarcoma, version 2.2012 featured updates to the NCCN guidelines

Margaret Von Mehren, Robert S. Benjamin, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad, Thomas F. DeLaney, Kristen N. Ganjoo, Suzanne George, Ricardo Gonzalez, Martin J. Heslin, John M. Kane, Joel Mayerson, Sean V McGarry, Christian Meyer, Richard J. O'Donnell, I. Benjamin Paz, John D. Pfeifer, Raphael E. Pollock, R. Lor Randall, Richard F. RiedelScott Schuetze, Karen D. Schupak, Herbert S. Schwartz, Sridhar Shankar, Brian A. Van Tine, Jeffrey Wayne, Hema Sundar, Nicole R. McMillian

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

The major changes to the 2012 and 2011 NCCN Guidelines for Soft Tissue Sarcoma pertain to the management of patients with gastrointestinal stromal tumors (GISTs) and desmoid tumors (aggressive fibromatosis). Postoperative imatinib following complete resection for primary GIST with no preoperative imatinib is now included as a category 1 recommendation for patients with intermediate or high risk of recurrence. The panel also reaffirmed the recommendation for preoperative use of imatinib in patients with GISTs that are resectable with negative margins but associated with significant surgical morbidity. Observation was included as an option for patients with resectable desmoid tumors that are small and asymptomatic, not causing morbidity, pain, or functional limitation. Sorafenib is included as an option for systemic therapy for patients with desmoid tumors.

Original languageEnglish (US)
Pages (from-to)951-960
Number of pages10
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2012

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Aggressive Fibromatosis
Sarcoma
Gastrointestinal Stromal Tumors
Guidelines
Morbidity
Neoplasms
Observation
Recurrence
Pain
Imatinib Mesylate

ASJC Scopus subject areas

  • Oncology

Cite this

Von Mehren, M., Benjamin, R. S., Bui, M. M., Casper, E. S., Conrad, E. U., DeLaney, T. F., ... McMillian, N. R. (2012). Soft tissue sarcoma, version 2.2012 featured updates to the NCCN guidelines. JNCCN Journal of the National Comprehensive Cancer Network, 10(8), 951-960. https://doi.org/10.6004/jnccn.2012.0099

Soft tissue sarcoma, version 2.2012 featured updates to the NCCN guidelines. / Von Mehren, Margaret; Benjamin, Robert S.; Bui, Marilyn M.; Casper, Ephraim S.; Conrad, Ernest U.; DeLaney, Thomas F.; Ganjoo, Kristen N.; George, Suzanne; Gonzalez, Ricardo; Heslin, Martin J.; Kane, John M.; Mayerson, Joel; McGarry, Sean V; Meyer, Christian; O'Donnell, Richard J.; Paz, I. Benjamin; Pfeifer, John D.; Pollock, Raphael E.; Randall, R. Lor; Riedel, Richard F.; Schuetze, Scott; Schupak, Karen D.; Schwartz, Herbert S.; Shankar, Sridhar; Van Tine, Brian A.; Wayne, Jeffrey; Sundar, Hema; McMillian, Nicole R.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 10, No. 8, 01.08.2012, p. 951-960.

Research output: Contribution to journalReview article

Von Mehren, M, Benjamin, RS, Bui, MM, Casper, ES, Conrad, EU, DeLaney, TF, Ganjoo, KN, George, S, Gonzalez, R, Heslin, MJ, Kane, JM, Mayerson, J, McGarry, SV, Meyer, C, O'Donnell, RJ, Paz, IB, Pfeifer, JD, Pollock, RE, Randall, RL, Riedel, RF, Schuetze, S, Schupak, KD, Schwartz, HS, Shankar, S, Van Tine, BA, Wayne, J, Sundar, H & McMillian, NR 2012, 'Soft tissue sarcoma, version 2.2012 featured updates to the NCCN guidelines', JNCCN Journal of the National Comprehensive Cancer Network, vol. 10, no. 8, pp. 951-960. https://doi.org/10.6004/jnccn.2012.0099
Von Mehren, Margaret ; Benjamin, Robert S. ; Bui, Marilyn M. ; Casper, Ephraim S. ; Conrad, Ernest U. ; DeLaney, Thomas F. ; Ganjoo, Kristen N. ; George, Suzanne ; Gonzalez, Ricardo ; Heslin, Martin J. ; Kane, John M. ; Mayerson, Joel ; McGarry, Sean V ; Meyer, Christian ; O'Donnell, Richard J. ; Paz, I. Benjamin ; Pfeifer, John D. ; Pollock, Raphael E. ; Randall, R. Lor ; Riedel, Richard F. ; Schuetze, Scott ; Schupak, Karen D. ; Schwartz, Herbert S. ; Shankar, Sridhar ; Van Tine, Brian A. ; Wayne, Jeffrey ; Sundar, Hema ; McMillian, Nicole R. / Soft tissue sarcoma, version 2.2012 featured updates to the NCCN guidelines. In: JNCCN Journal of the National Comprehensive Cancer Network. 2012 ; Vol. 10, No. 8. pp. 951-960.
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