Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Kamil Elkhoury, Carina S. Russell, Laura Sanchez-Gonzalez, Azadeh Mostafavi, Tyrell J. Williams, Cyril Kahn, Nicholas A. Peppas, Elmira Arab-Tehrany, Ali Tamayol

Research output: Contribution to journalReview article

Abstract

Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

Original languageEnglish (US)
Article number1900506
JournalAdvanced Healthcare Materials
Volume8
Issue number18
DOIs
StatePublished - Sep 1 2019

Fingerprint

Hydrogels
Tissue Engineering
Tissue engineering
Nanoparticles
Scaffolds (biology)
Tissue Scaffolds
Natural polymers
Cell growth
Drug Discovery
Growth
Research
Scaffolds
Fillers
Polymers
Modulation
Fabrication

Keywords

  • nanofunctionalization
  • natural hydrogels
  • soft nanoparticles
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Elkhoury, K., Russell, C. S., Sanchez-Gonzalez, L., Mostafavi, A., Williams, T. J., Kahn, C., ... Tamayol, A. (2019). Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications. Advanced Healthcare Materials, 8(18), [1900506]. https://doi.org/10.1002/adhm.201900506

Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications. / Elkhoury, Kamil; Russell, Carina S.; Sanchez-Gonzalez, Laura; Mostafavi, Azadeh; Williams, Tyrell J.; Kahn, Cyril; Peppas, Nicholas A.; Arab-Tehrany, Elmira; Tamayol, Ali.

In: Advanced Healthcare Materials, Vol. 8, No. 18, 1900506, 01.09.2019.

Research output: Contribution to journalReview article

Elkhoury, K, Russell, CS, Sanchez-Gonzalez, L, Mostafavi, A, Williams, TJ, Kahn, C, Peppas, NA, Arab-Tehrany, E & Tamayol, A 2019, 'Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications', Advanced Healthcare Materials, vol. 8, no. 18, 1900506. https://doi.org/10.1002/adhm.201900506
Elkhoury K, Russell CS, Sanchez-Gonzalez L, Mostafavi A, Williams TJ, Kahn C et al. Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications. Advanced Healthcare Materials. 2019 Sep 1;8(18). 1900506. https://doi.org/10.1002/adhm.201900506
Elkhoury, Kamil ; Russell, Carina S. ; Sanchez-Gonzalez, Laura ; Mostafavi, Azadeh ; Williams, Tyrell J. ; Kahn, Cyril ; Peppas, Nicholas A. ; Arab-Tehrany, Elmira ; Tamayol, Ali. / Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications. In: Advanced Healthcare Materials. 2019 ; Vol. 8, No. 18.
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