Abstract

MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)36-47
Number of pages12
JournalTrends in Molecular Medicine
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

MicroRNAs
Smoking
Neoplasms
Neoplasm Genes
Regulator Genes
Epigenomics
Lung Neoplasms
Biomarkers
Genes
Therapeutics

Keywords

  • Cancer
  • Diagnostic
  • Epigenetics
  • MiRNA
  • Signaling
  • Smoking

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Smoking and microRNA dysregulation : A cancerous combination. / Momi, Navneet; Kaur, Sukwinder; Rachagani, Satyanarayana; Ganti, Apar Kishor P; Batra, Surinder Kumar.

In: Trends in Molecular Medicine, Vol. 20, No. 1, 01.01.2014, p. 36-47.

Research output: Contribution to journalReview article

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