Smart Bandage for Monitoring and Treatment of Chronic Wounds

Pooria Mostafalu, Ali Tamayol, Rahim Rahimi, Manuel Ochoa, Akbar Khalilpour, Gita Kiaee, Iman K. Yazdi, Sara Bagherifard, Mehmet R. Dokmeci, Babak Ziaie, Sameer R. Sonkusale, Ali Khademhosseini

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to address this unmet medical need is presented. Moreover, a stimuli-responsive drug releasing system comprising of a hydrogel loaded with thermo-responsive drug carriers and an electronically controlled flexible heater is also integrated into the wound dressing to release the drugs on-demand. The dressing is equipped with a microcontroller to process the data measured by the sensors and to program the drug release protocol for individualized treatment. This flexible smart wound dressing has the potential to significantly impact the treatment of chronic wounds.

Original languageEnglish (US)
Article number1703509
JournalSmall
Volume14
Issue number33
DOIs
StatePublished - Aug 16 2018

Fingerprint

pH sensors
Temperature sensors
Bandages
Microcontrollers
Drug delivery
Hydrogels
Health
Monitoring
Sensors
Wounds and Injuries
Pharmaceutical Preparations
Drug Carriers
Hydrogel
Therapeutics
Clinical Protocols
Amputation
Extremities
Temperature

Keywords

  • automated systems
  • flexible electronics
  • on-demand drug delivery systems
  • pH sensors
  • smart bandages
  • wound healing

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Mostafalu, P., Tamayol, A., Rahimi, R., Ochoa, M., Khalilpour, A., Kiaee, G., ... Khademhosseini, A. (2018). Smart Bandage for Monitoring and Treatment of Chronic Wounds. Small, 14(33), [1703509]. https://doi.org/10.1002/smll.201703509

Smart Bandage for Monitoring and Treatment of Chronic Wounds. / Mostafalu, Pooria; Tamayol, Ali; Rahimi, Rahim; Ochoa, Manuel; Khalilpour, Akbar; Kiaee, Gita; Yazdi, Iman K.; Bagherifard, Sara; Dokmeci, Mehmet R.; Ziaie, Babak; Sonkusale, Sameer R.; Khademhosseini, Ali.

In: Small, Vol. 14, No. 33, 1703509, 16.08.2018.

Research output: Contribution to journalArticle

Mostafalu, P, Tamayol, A, Rahimi, R, Ochoa, M, Khalilpour, A, Kiaee, G, Yazdi, IK, Bagherifard, S, Dokmeci, MR, Ziaie, B, Sonkusale, SR & Khademhosseini, A 2018, 'Smart Bandage for Monitoring and Treatment of Chronic Wounds', Small, vol. 14, no. 33, 1703509. https://doi.org/10.1002/smll.201703509
Mostafalu P, Tamayol A, Rahimi R, Ochoa M, Khalilpour A, Kiaee G et al. Smart Bandage for Monitoring and Treatment of Chronic Wounds. Small. 2018 Aug 16;14(33). 1703509. https://doi.org/10.1002/smll.201703509
Mostafalu, Pooria ; Tamayol, Ali ; Rahimi, Rahim ; Ochoa, Manuel ; Khalilpour, Akbar ; Kiaee, Gita ; Yazdi, Iman K. ; Bagherifard, Sara ; Dokmeci, Mehmet R. ; Ziaie, Babak ; Sonkusale, Sameer R. ; Khademhosseini, Ali. / Smart Bandage for Monitoring and Treatment of Chronic Wounds. In: Small. 2018 ; Vol. 14, No. 33.
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