Small intestine mucosal adhesivity to in vivo capsule robot materials

Benjamin S. Terry, Anna C. Passernig, Morgan L. Hill, Jonathan A. Schoen, Mark E. Rentschler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Multiple research groups are investigating the feasibility of miniature, swallowable, in vivo, untethered robots that are capable of traversing the small intestine for the purpose of acquiring biometrics and performing simple surgical procedures. A mathematical model of the intraluminal environment will speed the development of these so-called Robotic Capsule Endoscopes (RCEs), and to this end, the authors, in previous work, initiated a comprehensive program for characterizing both the active and passive forces exerted by the small intestine on an RCE-sized solid bolus. In this work, forces due to adhesivity between RCE materials and the mucosa are investigated. The experimental factors are adhesive modality (peel and tack), material (polycarbonate, micropatterned polydimethylsiloxane, stainless steel, and mucosa), and bowel region (proximal, middle, and distal). The mucosa is excised from a fasting pig, stored in lactated ringer's solution at 3°C, and then tested at room temperature within 43h of excision. The results show the mean tack strength of the mucosa to engineering materials was 0.198±0.070mJcm-2. The mean peel strength was 0.055±0.016mJcm-2. This study marks the first time, to the authors' knowledge, that adhesivity between small intestinal mucosa and RCE engineering materials has been measured. The adhesivity values acquired from this study will provide a valuable input into analytical and numerical models of the gastrointestinal tract, specifically models that account for the interfacial properties of the tissue.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume15
DOIs
StatePublished - Oct 2 2012

Fingerprint

Endoscopy
Capsules
Robots
Robotics
polycarbonate
Stainless Steel
Polydimethylsiloxane
Biometrics
Polycarbonates
Numerical models
Analytical models
Adhesives
Stainless steel
Mucous Membrane
Tissue
Mathematical models
Temperature

Keywords

  • Mechanical characterization
  • Mucoadhesion
  • Mucosa adhesivity
  • Robotic capsule endoscope
  • Small bowel

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

Small intestine mucosal adhesivity to in vivo capsule robot materials. / Terry, Benjamin S.; Passernig, Anna C.; Hill, Morgan L.; Schoen, Jonathan A.; Rentschler, Mark E.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 15, 02.10.2012, p. 24-32.

Research output: Contribution to journalArticle

Terry, Benjamin S. ; Passernig, Anna C. ; Hill, Morgan L. ; Schoen, Jonathan A. ; Rentschler, Mark E. / Small intestine mucosal adhesivity to in vivo capsule robot materials. In: Journal of the Mechanical Behavior of Biomedical Materials. 2012 ; Vol. 15. pp. 24-32.
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