SLC31 (CTR) family of copper transporters in health and disease

Heejeong Kim, Xiaobin Wu, Jaekwon Lee

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Copper is a vital mineral for many organisms, yet it is highly toxic as demonstrated by serious health concerns associated with its deficiency or excess accumulation. The SLC31 (CTR) family of copper transporters is a major gateway of copper acquisition in eukaryotes, ranging from yeast to humans. Characterization of the function, modes of action, and regulation of CTR and other molecular factors that functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification has revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. This research progress further indicates the significance of copper in health and disease and opens avenues for therapeutic control of copper bioavailability and its metabolic pathways.

Original languageEnglish (US)
Pages (from-to)561-570
Number of pages10
JournalMolecular Aspects of Medicine
Volume34
Issue number2-3
DOIs
StatePublished - Apr 1 2013

Fingerprint

Copper
Health
Detoxification
Poisons
Metabolic Networks and Pathways
Eukaryota
Metabolism
Yeast
Biological Availability
Minerals
Yeasts
Research

Keywords

  • CTR
  • Cisplatin
  • Copper
  • Menkes disease
  • Metallochaperone
  • SLC31
  • Transporter
  • Wilson disease

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry
  • Medicine(all)

Cite this

SLC31 (CTR) family of copper transporters in health and disease. / Kim, Heejeong; Wu, Xiaobin; Lee, Jaekwon.

In: Molecular Aspects of Medicine, Vol. 34, No. 2-3, 01.04.2013, p. 561-570.

Research output: Contribution to journalReview article

Kim, Heejeong ; Wu, Xiaobin ; Lee, Jaekwon. / SLC31 (CTR) family of copper transporters in health and disease. In: Molecular Aspects of Medicine. 2013 ; Vol. 34, No. 2-3. pp. 561-570.
@article{d1fb4009eb6541a29362ce74ec536f04,
title = "SLC31 (CTR) family of copper transporters in health and disease",
abstract = "Copper is a vital mineral for many organisms, yet it is highly toxic as demonstrated by serious health concerns associated with its deficiency or excess accumulation. The SLC31 (CTR) family of copper transporters is a major gateway of copper acquisition in eukaryotes, ranging from yeast to humans. Characterization of the function, modes of action, and regulation of CTR and other molecular factors that functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification has revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. This research progress further indicates the significance of copper in health and disease and opens avenues for therapeutic control of copper bioavailability and its metabolic pathways.",
keywords = "CTR, Cisplatin, Copper, Menkes disease, Metallochaperone, SLC31, Transporter, Wilson disease",
author = "Heejeong Kim and Xiaobin Wu and Jaekwon Lee",
year = "2013",
month = "4",
day = "1",
doi = "10.1016/j.mam.2012.07.011",
language = "English (US)",
volume = "34",
pages = "561--570",
journal = "Molecular Aspects of Medicine",
issn = "0098-2997",
publisher = "Elsevier Limited",
number = "2-3",

}

TY - JOUR

T1 - SLC31 (CTR) family of copper transporters in health and disease

AU - Kim, Heejeong

AU - Wu, Xiaobin

AU - Lee, Jaekwon

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Copper is a vital mineral for many organisms, yet it is highly toxic as demonstrated by serious health concerns associated with its deficiency or excess accumulation. The SLC31 (CTR) family of copper transporters is a major gateway of copper acquisition in eukaryotes, ranging from yeast to humans. Characterization of the function, modes of action, and regulation of CTR and other molecular factors that functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification has revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. This research progress further indicates the significance of copper in health and disease and opens avenues for therapeutic control of copper bioavailability and its metabolic pathways.

AB - Copper is a vital mineral for many organisms, yet it is highly toxic as demonstrated by serious health concerns associated with its deficiency or excess accumulation. The SLC31 (CTR) family of copper transporters is a major gateway of copper acquisition in eukaryotes, ranging from yeast to humans. Characterization of the function, modes of action, and regulation of CTR and other molecular factors that functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification has revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. This research progress further indicates the significance of copper in health and disease and opens avenues for therapeutic control of copper bioavailability and its metabolic pathways.

KW - CTR

KW - Cisplatin

KW - Copper

KW - Menkes disease

KW - Metallochaperone

KW - SLC31

KW - Transporter

KW - Wilson disease

UR - http://www.scopus.com/inward/record.url?scp=84875166413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875166413&partnerID=8YFLogxK

U2 - 10.1016/j.mam.2012.07.011

DO - 10.1016/j.mam.2012.07.011

M3 - Review article

VL - 34

SP - 561

EP - 570

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

SN - 0098-2997

IS - 2-3

ER -