Sjögren's syndrome in patients with primary biliary cirrhosis

Epaminondas V. Tsianos, Jay H. Hoofnagle, Philip C. Fox, Margaret Alspaugh, E. Anthony Jones, Daniel F. Schafer, Haralampos M. Moutsopoulos

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%). Nineteen patients consented to evaluation for Sjögren's syndrome, which included Schirmer's I test, measurement of parotid flow rate and serum autoantibodies, labial minor salivary gland biopsy and human leukocyte antigen typing. Histological changes diagnostic of Sjögren's syndrome were present in five patients (26.3%). All five patients had symptoms of Sjögren's syndrome and three had abnormal Schirmer's I tests, but none had corneal ulcerations or decreased parotid flow rates. Results of serological tests and human leukocyte antigen typing were not similar to those described in patients with primary Sjögren's syndrome but were similar to those described in patients with rheumatoid arthritis and Sjögren's syndrome associated with primary biliary cirrhosis is a form of secondary Sjögren's syndrome resembling that associated with rheumatoid arthritis.(HEPATOLOGY 1990; 11:730‐734.)

Original languageEnglish (US)
Pages (from-to)730-734
Number of pages5
JournalHepatology
Volume11
Issue number5
DOIs
StatePublished - May 1990

Fingerprint

Biliary Liver Cirrhosis
HLA Antigens
Rheumatoid Arthritis
Minor Salivary Glands
Serologic Tests
Lip
Autoantibodies
Biopsy
Serum

ASJC Scopus subject areas

  • Hepatology

Cite this

Tsianos, E. V., Hoofnagle, J. H., Fox, P. C., Alspaugh, M., Jones, E. A., Schafer, D. F., & Moutsopoulos, H. M. (1990). Sjögren's syndrome in patients with primary biliary cirrhosis. Hepatology, 11(5), 730-734. https://doi.org/10.1002/hep.1840110504

Sjögren's syndrome in patients with primary biliary cirrhosis. / Tsianos, Epaminondas V.; Hoofnagle, Jay H.; Fox, Philip C.; Alspaugh, Margaret; Jones, E. Anthony; Schafer, Daniel F.; Moutsopoulos, Haralampos M.

In: Hepatology, Vol. 11, No. 5, 05.1990, p. 730-734.

Research output: Contribution to journalArticle

Tsianos, EV, Hoofnagle, JH, Fox, PC, Alspaugh, M, Jones, EA, Schafer, DF & Moutsopoulos, HM 1990, 'Sjögren's syndrome in patients with primary biliary cirrhosis', Hepatology, vol. 11, no. 5, pp. 730-734. https://doi.org/10.1002/hep.1840110504
Tsianos EV, Hoofnagle JH, Fox PC, Alspaugh M, Jones EA, Schafer DF et al. Sjögren's syndrome in patients with primary biliary cirrhosis. Hepatology. 1990 May;11(5):730-734. https://doi.org/10.1002/hep.1840110504
Tsianos, Epaminondas V. ; Hoofnagle, Jay H. ; Fox, Philip C. ; Alspaugh, Margaret ; Jones, E. Anthony ; Schafer, Daniel F. ; Moutsopoulos, Haralampos M. / Sjögren's syndrome in patients with primary biliary cirrhosis. In: Hepatology. 1990 ; Vol. 11, No. 5. pp. 730-734.
@article{452f32f9ae9c473fb56aca4261c940df,
title = "Sj{\"o}gren's syndrome in patients with primary biliary cirrhosis",
abstract = "Symptomatology and objective findings of Sj{\"o}gren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sj{\"o}gren's syndrome were present in 18 (47.4{\%}) patients, but were severe enough to warrant therapy in only four (10.5{\%}). Nineteen patients consented to evaluation for Sj{\"o}gren's syndrome, which included Schirmer's I test, measurement of parotid flow rate and serum autoantibodies, labial minor salivary gland biopsy and human leukocyte antigen typing. Histological changes diagnostic of Sj{\"o}gren's syndrome were present in five patients (26.3{\%}). All five patients had symptoms of Sj{\"o}gren's syndrome and three had abnormal Schirmer's I tests, but none had corneal ulcerations or decreased parotid flow rates. Results of serological tests and human leukocyte antigen typing were not similar to those described in patients with primary Sj{\"o}gren's syndrome but were similar to those described in patients with rheumatoid arthritis and Sj{\"o}gren's syndrome associated with primary biliary cirrhosis is a form of secondary Sj{\"o}gren's syndrome resembling that associated with rheumatoid arthritis.(HEPATOLOGY 1990; 11:730‐734.)",
author = "Tsianos, {Epaminondas V.} and Hoofnagle, {Jay H.} and Fox, {Philip C.} and Margaret Alspaugh and Jones, {E. Anthony} and Schafer, {Daniel F.} and Moutsopoulos, {Haralampos M.}",
year = "1990",
month = "5",
doi = "10.1002/hep.1840110504",
language = "English (US)",
volume = "11",
pages = "730--734",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - Sjögren's syndrome in patients with primary biliary cirrhosis

AU - Tsianos, Epaminondas V.

AU - Hoofnagle, Jay H.

AU - Fox, Philip C.

AU - Alspaugh, Margaret

AU - Jones, E. Anthony

AU - Schafer, Daniel F.

AU - Moutsopoulos, Haralampos M.

PY - 1990/5

Y1 - 1990/5

N2 - Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%). Nineteen patients consented to evaluation for Sjögren's syndrome, which included Schirmer's I test, measurement of parotid flow rate and serum autoantibodies, labial minor salivary gland biopsy and human leukocyte antigen typing. Histological changes diagnostic of Sjögren's syndrome were present in five patients (26.3%). All five patients had symptoms of Sjögren's syndrome and three had abnormal Schirmer's I tests, but none had corneal ulcerations or decreased parotid flow rates. Results of serological tests and human leukocyte antigen typing were not similar to those described in patients with primary Sjögren's syndrome but were similar to those described in patients with rheumatoid arthritis and Sjögren's syndrome associated with primary biliary cirrhosis is a form of secondary Sjögren's syndrome resembling that associated with rheumatoid arthritis.(HEPATOLOGY 1990; 11:730‐734.)

AB - Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%). Nineteen patients consented to evaluation for Sjögren's syndrome, which included Schirmer's I test, measurement of parotid flow rate and serum autoantibodies, labial minor salivary gland biopsy and human leukocyte antigen typing. Histological changes diagnostic of Sjögren's syndrome were present in five patients (26.3%). All five patients had symptoms of Sjögren's syndrome and three had abnormal Schirmer's I tests, but none had corneal ulcerations or decreased parotid flow rates. Results of serological tests and human leukocyte antigen typing were not similar to those described in patients with primary Sjögren's syndrome but were similar to those described in patients with rheumatoid arthritis and Sjögren's syndrome associated with primary biliary cirrhosis is a form of secondary Sjögren's syndrome resembling that associated with rheumatoid arthritis.(HEPATOLOGY 1990; 11:730‐734.)

UR - http://www.scopus.com/inward/record.url?scp=0025192029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025192029&partnerID=8YFLogxK

U2 - 10.1002/hep.1840110504

DO - 10.1002/hep.1840110504

M3 - Article

C2 - 2347546

AN - SCOPUS:0025192029

VL - 11

SP - 730

EP - 734

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 5

ER -