SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model

Mehdi R.M. Bidokhti, Debashis Dutta, Lepakshe S.V. Madduri, Shawna M. Woollard, Robert B Norgren, Luis Giavedoni, Siddappa Nagadenahalli Byrareddy

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Abstract

Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (SIV/SHIV) and then inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV co-infected animals revealed no significant changes as compared to animals that were infected with ZIKV alone or as compared to SIV/SHIV infected animals prior to ZIKV inoculation. ZIKV tissue clearance of co-infected animals was similar to animals that were infected with ZIKV alone. Furthermore, in co-infected macaques, there was no statistically significant difference in plasma cytokines/chemokines levels as compared to prior to ZIKV inoculation. Collectively, these findings suggest that co-infection may not alter disease pathogenesis, thus warranting larger HIV-ZIKV epidemiological studies in order to validate these findings.

Original languageEnglish (US)
Pages (from-to)e0006811
JournalPLoS Neglected Tropical Diseases
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2018

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Simian Immunodeficiency Virus
Macaca mulatta
Coinfection
HIV
Macaca
Zika Virus
Virus Diseases
Viral Load
Chemokines
Epidemiologic Studies
Animal Models
Cytokines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model. / Bidokhti, Mehdi R.M.; Dutta, Debashis; Madduri, Lepakshe S.V.; Woollard, Shawna M.; Norgren, Robert B; Giavedoni, Luis; Byrareddy, Siddappa Nagadenahalli.

In: PLoS Neglected Tropical Diseases, Vol. 12, No. 10, 01.10.2018, p. e0006811.

Research output: Contribution to journalArticle

Bidokhti, Mehdi R.M. ; Dutta, Debashis ; Madduri, Lepakshe S.V. ; Woollard, Shawna M. ; Norgren, Robert B ; Giavedoni, Luis ; Byrareddy, Siddappa Nagadenahalli. / SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model. In: PLoS Neglected Tropical Diseases. 2018 ; Vol. 12, No. 10. pp. e0006811.
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