Sister-chromatid exchanges and chromosomal aberrations in rats treated with phenacetin, phenazone and caffeine

Ingrid Granberg-Öhman, S. Johansson, A. Hjerpe

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

To study chromosomal aberrations and the frequency of sister-chromatid exchanges (SCE) a long-term chronic toxicity study was performed in rats treated with phenacetin, phenazone and caffeine, alone and in different combinations. Compared with controls, aberrations such as gaps, breaks and structural dearrangements were only increased in the group treated by phenacetin alone. After mitomycin C treatment of the blood culture, the aberrations were markedly, but not significantly, increased. All experimental groups showed a higher SCE frequency, most deviating in the rats treated with phenacetin alone. This correlates with the fact that phenacetin is a strong general carcinogen.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalMutation Research - Genetic Toxicology
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1 1980

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ASJC Scopus subject areas

  • Toxicology
  • Genetics

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