Sinonasal adenoid cystic carcinoma

Treatment outcomes and association with human papillomavirus

Eric D. Miller, Dukagjin M. Blakaj, Benjamin J Swanson, Weihong Xiao, Maura L. Gillison, Lai Wei, Aashish D. Bhatt, Virginia M. Diavolitsis, Jessica L. Wobb, Stephen Y. Kang, Ricardo L. Carrau, John C. Grecula

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - 2017
Externally publishedYes

Fingerprint

Adenoid Cystic Carcinoma
Papillomavirus Infections
Disease-Free Survival
Medical Records
Immunohistochemistry
Staining and Labeling
Polymerase Chain Reaction
Survival

Keywords

  • Adenoid cystic carcinoma
  • Human papillomavirus
  • P16
  • Paranasal sinus neoplasms
  • Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Miller, E. D., Blakaj, D. M., Swanson, B. J., Xiao, W., Gillison, M. L., Wei, L., ... Grecula, J. C. (Accepted/In press). Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus. Head and Neck. https://doi.org/10.1002/hed.24778

Sinonasal adenoid cystic carcinoma : Treatment outcomes and association with human papillomavirus. / Miller, Eric D.; Blakaj, Dukagjin M.; Swanson, Benjamin J; Xiao, Weihong; Gillison, Maura L.; Wei, Lai; Bhatt, Aashish D.; Diavolitsis, Virginia M.; Wobb, Jessica L.; Kang, Stephen Y.; Carrau, Ricardo L.; Grecula, John C.

In: Head and Neck, 2017.

Research output: Contribution to journalArticle

Miller, ED, Blakaj, DM, Swanson, BJ, Xiao, W, Gillison, ML, Wei, L, Bhatt, AD, Diavolitsis, VM, Wobb, JL, Kang, SY, Carrau, RL & Grecula, JC 2017, 'Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus', Head and Neck. https://doi.org/10.1002/hed.24778
Miller, Eric D. ; Blakaj, Dukagjin M. ; Swanson, Benjamin J ; Xiao, Weihong ; Gillison, Maura L. ; Wei, Lai ; Bhatt, Aashish D. ; Diavolitsis, Virginia M. ; Wobb, Jessica L. ; Kang, Stephen Y. ; Carrau, Ricardo L. ; Grecula, John C. / Sinonasal adenoid cystic carcinoma : Treatment outcomes and association with human papillomavirus. In: Head and Neck. 2017.
@article{875c0fb0fb064a57b3c26fd24aa0e9d8,
title = "Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus",
abstract = "Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51{\%}, 52{\%}, and 62{\%}, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.",
keywords = "Adenoid cystic carcinoma, Human papillomavirus, P16, Paranasal sinus neoplasms, Radiotherapy",
author = "Miller, {Eric D.} and Blakaj, {Dukagjin M.} and Swanson, {Benjamin J} and Weihong Xiao and Gillison, {Maura L.} and Lai Wei and Bhatt, {Aashish D.} and Diavolitsis, {Virginia M.} and Wobb, {Jessica L.} and Kang, {Stephen Y.} and Carrau, {Ricardo L.} and Grecula, {John C.}",
year = "2017",
doi = "10.1002/hed.24778",
language = "English (US)",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Sinonasal adenoid cystic carcinoma

T2 - Treatment outcomes and association with human papillomavirus

AU - Miller, Eric D.

AU - Blakaj, Dukagjin M.

AU - Swanson, Benjamin J

AU - Xiao, Weihong

AU - Gillison, Maura L.

AU - Wei, Lai

AU - Bhatt, Aashish D.

AU - Diavolitsis, Virginia M.

AU - Wobb, Jessica L.

AU - Kang, Stephen Y.

AU - Carrau, Ricardo L.

AU - Grecula, John C.

PY - 2017

Y1 - 2017

N2 - Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

AB - Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV). Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. The p16 testing was performed using immunohistochemistry (IHC), and HPV infection was determined using quantitative polymerase chain reaction (PCR) with primers targeting the E6/E7 region. Results: Two of the 17 samples showed strong and diffuse p16 staining, whereas the remaining 15 cases showed p16-positivity isolated to the luminal cells. Only one of the p16-positive cases was positive for HPV. The 5-year local failure, disease-free survival (DFS), and overall survival (OS) were 51%, 52%, and 62%, respectively. Conclusion: Local failures are common with advanced sinonasal ACC, and the association of HPV with true sinonasal ACC is low.

KW - Adenoid cystic carcinoma

KW - Human papillomavirus

KW - P16

KW - Paranasal sinus neoplasms

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85017161548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017161548&partnerID=8YFLogxK

U2 - 10.1002/hed.24778

DO - 10.1002/hed.24778

M3 - Article

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

ER -