Single-unit responses to cholinergic agents in the rat inferior colliculus

Glenn R. Farley, Barbara J Morley, Eric Javel, Michael P Gorga

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Single units were recorded from the inferior colliculi of adult male rats anesthetized with urethane. Units were driven with tonal stimuli, and changes in unit responses to the tones were monitored during iontophoretic application of cholinergic drugs. The cholinergic agonists acetylcholine and carbamylcholine potentiated responses in about 50% and suppressed responses in about 35% of units tested. Cholinergic antagonists typically produced effects when delivered alone. Both d-tubocurarine and atropine methyl nitrate excited over 80% of units tested, while mecamylamine and scopolamine inhibited the majority of tested units. Dihydro-beta-erythroidine was generally ineffective. Alpha-bungarotoxin was generally ineffective when delivered alone, but blocked agonist effects. Post-stimulus time histogram (PSTH) patterns, response-intensity functions and response areas were examined for changes during drug delivery. Cholinergic agents did not differentially affect either time periods within the PSTH or frequency bands of response areas, but were especially effective for those intensities producing larger response rates. Taken together with evidence from biochemical studies, our results suggest the presence of a functional cholinergic input into the inferior colliculus which acts to modulate acoustic processing.

Original languageEnglish (US)
Pages (from-to)73-91
Number of pages19
JournalHearing Research
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1983

Fingerprint

Inferior Colliculi
Cholinergic Agents
Dihydro-beta-Erythroidine
Mecamylamine
Bungarotoxins
Cholinergic Agonists
Tubocurarine
Scopolamine Hydrobromide
Urethane
Cholinergic Antagonists
Carbachol
Atropine
Acoustics
Acetylcholine
Pharmaceutical Preparations

Keywords

  • auditory
  • cholinergic effects
  • inferior colliculus
  • iontophoresis

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Single-unit responses to cholinergic agents in the rat inferior colliculus. / Farley, Glenn R.; Morley, Barbara J; Javel, Eric; Gorga, Michael P.

In: Hearing Research, Vol. 11, No. 1, 01.01.1983, p. 73-91.

Research output: Contribution to journalArticle

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