Single muscle fiber adaptations with marathon training

Scott Trappe, Matthew Harber, Andrew Creer, Philip Gallagher, Dustin R Slivka, Kiril Minchev, David Whitsett

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The purpose of this investigation was to characterize the effects of marathon training on single muscle fiber contractile function in a group of recreational runners. Muscle biopsies were obtained from the gastrocnemius muscle of seven individuals (22 ± 1 yr, 177 ± 3 cm, and 68 ± 2 kg) before, after 13 wk of run training, and after 3 wk of taper. Slow-twitch myosin heavy chain [(MHC) I] and fast-twitch (MHC IIa) muscle fibers were analyzed for size, strength (Po), speed (Vo), and power. The run training program led to the successful completion of a marathon (range 3 h 56 min to 5 h 35 min). Oxygen uptake during submaximal running and citrate synthase activity were improved (P < 0.05) with the training program. Muscle fiber size declined (P < 0.05) by ∼20% in both fiber types after training. Po was maintained in both fiber types with training and increased (P < 0.05) by 18% in the MHC IIa fibers after taper. This resulted in >60% increase (P < 0.05) in force per cross-sectional area in both fiber types. Fiber Vo increased (P < 0.05) by 28% in MHC I fibers with training and was unchanged in MHC IIa fibers. Peak power increased (P < 0.05) in MHC I and IIa fibers after training with a further increase (P < 0.05) in MHC IIa fiber power after taper. These data show that marathon training decreased slow-twitch and fast-twitch muscle fiber size but that it maintained or improved the functional profile of these fibers. A taper period before the marathon further improved the functional profile of the muscle, which was targeted to the fast-twitch muscle fibers.

Original languageEnglish (US)
Pages (from-to)721-727
Number of pages7
JournalJournal of Applied Physiology
Volume101
Issue number3
DOIs
StatePublished - Sep 14 2006

Fingerprint

Myosin Heavy Chains
Muscles
Fast-Twitch Muscle Fibers
Citrate (si)-Synthase
Skeletal Muscle
Oxygen
Biopsy
Education

Keywords

  • Contractile properties
  • Performance
  • Taper

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Trappe, S., Harber, M., Creer, A., Gallagher, P., Slivka, D. R., Minchev, K., & Whitsett, D. (2006). Single muscle fiber adaptations with marathon training. Journal of Applied Physiology, 101(3), 721-727. https://doi.org/10.1152/japplphysiol.01595.2005

Single muscle fiber adaptations with marathon training. / Trappe, Scott; Harber, Matthew; Creer, Andrew; Gallagher, Philip; Slivka, Dustin R; Minchev, Kiril; Whitsett, David.

In: Journal of Applied Physiology, Vol. 101, No. 3, 14.09.2006, p. 721-727.

Research output: Contribution to journalArticle

Trappe, S, Harber, M, Creer, A, Gallagher, P, Slivka, DR, Minchev, K & Whitsett, D 2006, 'Single muscle fiber adaptations with marathon training', Journal of Applied Physiology, vol. 101, no. 3, pp. 721-727. https://doi.org/10.1152/japplphysiol.01595.2005
Trappe, Scott ; Harber, Matthew ; Creer, Andrew ; Gallagher, Philip ; Slivka, Dustin R ; Minchev, Kiril ; Whitsett, David. / Single muscle fiber adaptations with marathon training. In: Journal of Applied Physiology. 2006 ; Vol. 101, No. 3. pp. 721-727.
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