Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia

Tae H. Kim, John H. Kersey, Faiz M. Khan, Wilfred Sewchand, Norma Ramsey, William Krivit, Peter Coccia, Mark E. Nesbit, Seymour H. Levitt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Six patients with aplastic anemia underwent bone marrow transplantation following conditioning with high dose cyclophosphamide and single dose total lymphoid irradiation with 750 rad, 26 rad/min at the midplane of the patient. They all received bone marrow from human leukocyte antigens/mixed lymphocyte culture (HLA/MLC) matched siblings. Five of 6 patients were alive without complications at 12, 11, 7, 4 and 4 months respectively. The remaining patient died from sepsis which he had prior to transplantation. There were no graft rejection, graft-vs-Host Disease (GVHD) or interstitial pneumonitis among these patients. The procedure was well tolerated with minimal side effects. The results will be compared with those of groups whose bone marrow was previously transplanted with different immunosuppressive methods.

Original languageEnglish (US)
Pages (from-to)993-996
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume5
Issue number7
DOIs
StatePublished - Jul 1979

Fingerprint

immunosuppression
Lymphatic Irradiation
anemias
transplantation
Aplastic Anemia
Cyclophosphamide
Immunosuppression
Transplantation
Bone Marrow
bone marrow
dosage
irradiation
Transplantation Conditioning
leukocytes
lymphocytes
Interstitial Lung Diseases
Graft Rejection
antigens
Graft vs Host Disease
Immunosuppressive Agents

Keywords

  • Aplastic anemia
  • Bone marrow transplantation
  • Total lymphoid irradiation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia. / Kim, Tae H.; Kersey, John H.; Khan, Faiz M.; Sewchand, Wilfred; Ramsey, Norma; Krivit, William; Coccia, Peter; Nesbit, Mark E.; Levitt, Seymour H.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 5, No. 7, 07.1979, p. 993-996.

Research output: Contribution to journalArticle

Kim, Tae H. ; Kersey, John H. ; Khan, Faiz M. ; Sewchand, Wilfred ; Ramsey, Norma ; Krivit, William ; Coccia, Peter ; Nesbit, Mark E. ; Levitt, Seymour H. / Single dose total lymphoid irradiation combined with cyclophosphamide as immunosuppression for human marrow transplantation in aplastic anemia. In: International Journal of Radiation Oncology, Biology, Physics. 1979 ; Vol. 5, No. 7. pp. 993-996.
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