Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls

Caroline T.J. Lamers, Matthew Rizzo, Antoine Bechara, Jan Ramaekers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The aim of the study is to assess if cognitive impairments in abstinent users of methylenedioxymethamphetamine (MDMA) are due to repeated use of MDMA or concurrent drugs of abuse and how these impairments interfere with key activities of daily life such as automobile driving. Simulated driving performance and attention of 12 users of MDMA and marijuana [tetrahydrocannabinol (THC)] (MDMA/THC), 15 THC users, and 15 non-drug-using, age-matched controls were compared. THC users' mean speed reduction in response to passing a car parked on the shoulder of the road was 7 mph (11.3 km/h) less than that of controls. Compared with non-drug-using controls, the MDMA/THC users were less able to mitigate the effects of an illegal intersection incursion by another vehicle and entered the collision at a higher speed (42 versus 26 mph). In real life, this 16-mph (26-km/h) difference would increase the likelihood of injuring parties in both colliding vehicles. Processing speed and attention did not differ between groups; this suggests that the lower speed reduction in the MDMA/THC users was more likely due to executive function impairments (incorrect situation interpretation and awareness) than to reduced processing speed. In conclusion, compared with non-drug users, MDMA/THC users may be at a greater risk for driver performance errors that lead to crashes. Because collision speed did not differ between MDMA/THC users and THC users, a specific role of MDMA as opposed to THC toxicity in driving performance impairment remains to be established.

Original languageEnglish (US)
Title of host publicationHighway Safety
PublisherNational Research Council
Pages50-57
Number of pages8
Edition1969
ISBN (Print)0309099781, 9780309099783
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Publication series

NameTransportation Research Record
Number1969
ISSN (Print)0361-1981

Fingerprint

Processing
Automobiles
Toxicity
Railroad cars

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Mechanical Engineering

Cite this

Lamers, C. T. J., Rizzo, M., Bechara, A., & Ramaekers, J. (2006). Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. In Highway Safety (1969 ed., pp. 50-57). (Transportation Research Record; No. 1969). National Research Council. https://doi.org/10.3141/1969-09

Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. / Lamers, Caroline T.J.; Rizzo, Matthew; Bechara, Antoine; Ramaekers, Jan.

Highway Safety. 1969. ed. National Research Council, 2006. p. 50-57 (Transportation Research Record; No. 1969).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lamers, CTJ, Rizzo, M, Bechara, A & Ramaekers, J 2006, Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. in Highway Safety. 1969 edn, Transportation Research Record, no. 1969, National Research Council, pp. 50-57. https://doi.org/10.3141/1969-09
Lamers CTJ, Rizzo M, Bechara A, Ramaekers J. Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. In Highway Safety. 1969 ed. National Research Council. 2006. p. 50-57. (Transportation Research Record; 1969). https://doi.org/10.3141/1969-09
Lamers, Caroline T.J. ; Rizzo, Matthew ; Bechara, Antoine ; Ramaekers, Jan. / Simulated driving and attention of repeat users of MDMA and THC compared with THC users and non-drug-using controls. Highway Safety. 1969. ed. National Research Council, 2006. pp. 50-57 (Transportation Research Record; 1969).
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