Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents

Martin Conda-Sheridan, Venkatareddy Udumula, Jennifer L. Endres, Caleb N. Harper, Lee Jaramillo, Haizhen A. Zhong, Kenneth W. Bayles

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has become a severe health concern because of its treatment difficulties. Herein, we report the synthesis and biological evaluation of two phenazine natural products and a series of phenazines that show promising activities against MRSA with MIC values in the low micromolar range. Basic studies revealed that these compounds are bacteriostatic agents. The most active compound also displayed promising IC50 values against HaCat cells. Finally, a QSAR model was developed to understand the key structural features of the molecules.

Original languageEnglish (US)
Pages (from-to)710-721
Number of pages12
JournalEuropean Journal of Medicinal Chemistry
Volume125
DOIs
StatePublished - Jan 1 2017

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Keywords

  • Antibacterial Agents
  • Bacterial Infections
  • Drug-resistant Bacteria
  • MRSA
  • Methicillin-Resistant Staphylococcus Aureus
  • Natural Product Synthesis
  • Phenazines

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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