Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques

M. Von Herrath, M. B.A. Oldstone, H. S. Fox

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Simian immunodeficiency virus (SIV)-specific CD8+ CTL were isolated from blood, cerebrospinal fluid, and brains of rhesus macaques infected i.v. with SIV. CTL were found as early as 1 wk postinfection and their appearance correlated with a decrease of viral Ag (p27) found in the blood. CTL isolated from cerebrospinal fluid and/or brain often recognized different viral proteins than CTL isolated from blood, suggesting either a unique migratory pattern to the central nervous system or a difference in activation/retention of lymphocytes in these compartments.

Original languageEnglish (US)
Pages (from-to)5582-5589
Number of pages8
JournalJournal of Immunology
Issue number10
StatePublished - Jan 1 1995


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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