Significance of MUM-1/IRF4 protein expression in follicular lymphoma

Ying Ying Huo, Yi Pan, Bing Xin Guan, Ai Ju Fang, Bao Cun Sun, Geng Yin Zhou, Kai Fu, Bin Meng

Research output: Contribution to journalArticle

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Abstract

Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25% ) were 39. 8% ( 39/98 ) , 62.2% ( 61/98 ) , 80.6% ( 79/98 ) , 87.8% ( 86/98 ) and 50.0% ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)528-531
Number of pages4
JournalChinese Journal of Pathology
Volume40
Issue number8
DOIs
StatePublished - Aug 8 2011

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Follicular Lymphoma
Non-Hodgkin's Lymphoma
Proteins
Lymphoma
Immunohistochemistry

Keywords

  • Follicular
  • Immunohistochemistry
  • Lymphoma
  • Microarray analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huo, Y. Y., Pan, Y., Guan, B. X., Fang, A. J., Sun, B. C., Zhou, G. Y., ... Meng, B. (2011). Significance of MUM-1/IRF4 protein expression in follicular lymphoma. Chinese Journal of Pathology, 40(8), 528-531. https://doi.org/10.3760/cma.j.issn.0529-5807.2011.08.006

Significance of MUM-1/IRF4 protein expression in follicular lymphoma. / Huo, Ying Ying; Pan, Yi; Guan, Bing Xin; Fang, Ai Ju; Sun, Bao Cun; Zhou, Geng Yin; Fu, Kai; Meng, Bin.

In: Chinese Journal of Pathology, Vol. 40, No. 8, 08.08.2011, p. 528-531.

Research output: Contribution to journalArticle

Huo, YY, Pan, Y, Guan, BX, Fang, AJ, Sun, BC, Zhou, GY, Fu, K & Meng, B 2011, 'Significance of MUM-1/IRF4 protein expression in follicular lymphoma', Chinese Journal of Pathology, vol. 40, no. 8, pp. 528-531. https://doi.org/10.3760/cma.j.issn.0529-5807.2011.08.006
Huo, Ying Ying ; Pan, Yi ; Guan, Bing Xin ; Fang, Ai Ju ; Sun, Bao Cun ; Zhou, Geng Yin ; Fu, Kai ; Meng, Bin. / Significance of MUM-1/IRF4 protein expression in follicular lymphoma. In: Chinese Journal of Pathology. 2011 ; Vol. 40, No. 8. pp. 528-531.
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abstract = "Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25{\%} ) were 39. 8{\%} ( 39/98 ) , 62.2{\%} ( 61/98 ) , 80.6{\%} ( 79/98 ) , 87.8{\%} ( 86/98 ) and 50.0{\%} ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.",
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T1 - Significance of MUM-1/IRF4 protein expression in follicular lymphoma

AU - Huo, Ying Ying

AU - Pan, Yi

AU - Guan, Bing Xin

AU - Fang, Ai Ju

AU - Sun, Bao Cun

AU - Zhou, Geng Yin

AU - Fu, Kai

AU - Meng, Bin

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N2 - Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25% ) were 39. 8% ( 39/98 ) , 62.2% ( 61/98 ) , 80.6% ( 79/98 ) , 87.8% ( 86/98 ) and 50.0% ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.

AB - Objective To study the expression of MUM-1/IRF4 and its significance in follicular lymphoma. Methods Ninety-eight cases of follicular lymphoma were enrolled into the study. They were graded according to the 2008 WHO criteria. The expression of MUM-1/IRF4 protein and other markers (CDlO, bcl-6, bcl-2 and Ki-67) was studied using tissue microarray and immunohistochemistry. Results Amongst the 98 cases studied, there were 24 grade 1 cases, 30 grade 2 cases, 26 grade 3A cases and 18 were grade 3B cases. The rates of expression of MUM-1/IRF4, CD10, bcl-6, bcl-2 and Ki-67 ( ≥25% ) were 39. 8% ( 39/98 ) , 62.2% ( 61/98 ) , 80.6% ( 79/98 ) , 87.8% ( 86/98 ) and 50.0% ( 49/98 ) , respectively. MUM-1/IRF4 predominantly expressed in high-grade follicular lymphoma and showed a significantly positive correlation with lymphoma grade ( r = 0.628 ,P=0.000) and Ki-67 index ( r = 0.473 , P = 0.000). MUM-1/IRF4 expression had a significantly negative correlation with CD10 expression (r = -0.597 ,P =0.000) , but no correlation with bcl-6 and bcl-2 expression. Conclusions MUM-1/IRF4 expression is significantly higher in high-grade follicular lymphoma, indicating that these cases have a high proliferative activity, more aggressive behavior and poorer prognosis. MUM-1/IRF4, when strongly expressed, is another helpful marker for the diagnosis of high-grade follicular lymphoma.

KW - Follicular

KW - Immunohistochemistry

KW - Lymphoma

KW - Microarray analysis

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