Significance of isolated vasculitis in the gynecological tract: What clinicians do with the pathologic diagnosis of vasculitis?

Andres A. Roma, Catalina Amador-Ortiz, Helen Liapis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little known. We performed a 20 year retrospective review including 53 cases with vasculitis diagnosis affecting the female genital tract identified in pathology reports. None had prior symptoms or were diagnosed with generalized vasculitis, while one patient had prior diagnosis of fibromyalgia. Most patients presented with abnormal bleeding and were treated for conditions unrelated to vasculitis. The different types of vasculitis were: predominantly lymphocytic (nonspecific) 30 cases, necrotizing 17 cases and granulomatous 6 cases. Only 2 patients had additional serologic tests. None of the patients with isolated gynecologic vasculitis received corticosteroids or additional treatment related to the vasculitis. None of the patients developed systemic vasculitis at follow-up (2 months-19.5 years; mean, 5.5 years). Isolated gynecologic vasculitis diagnosed on pathology slides is rarely associated with systemic vasculitis. Potential isolated gynecologic vasculitis causes include: previous surgical interventions and vascular inflammation secondary to local neoplasm. In almost all cases, clinicians did not perform a thorough laboratory analysis to exclude systemic vasculitis and therapy was not required in any case, suggesting minimal clinical significance.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalAnnals of Diagnostic Pathology
Volume18
Issue number4
DOIs
StatePublished - Aug 2014

Fingerprint

Vasculitis
Systemic Vasculitis
Pathology
Blood Vessels
Inflammation
Fibromyalgia
Serologic Tests
Adrenal Cortex Hormones
Hemorrhage
Kidney

Keywords

  • Gynecological vasculitis
  • Isolated vasculitis
  • Systemic vasculitis
  • Vasculitides
  • Vasculitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Significance of isolated vasculitis in the gynecological tract : What clinicians do with the pathologic diagnosis of vasculitis? / Roma, Andres A.; Amador-Ortiz, Catalina; Liapis, Helen.

In: Annals of Diagnostic Pathology, Vol. 18, No. 4, 08.2014, p. 199-202.

Research output: Contribution to journalArticle

@article{4de626ad0e77439bbd3a18ea8f244531,
title = "Significance of isolated vasculitis in the gynecological tract: What clinicians do with the pathologic diagnosis of vasculitis?",
abstract = "Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little known. We performed a 20 year retrospective review including 53 cases with vasculitis diagnosis affecting the female genital tract identified in pathology reports. None had prior symptoms or were diagnosed with generalized vasculitis, while one patient had prior diagnosis of fibromyalgia. Most patients presented with abnormal bleeding and were treated for conditions unrelated to vasculitis. The different types of vasculitis were: predominantly lymphocytic (nonspecific) 30 cases, necrotizing 17 cases and granulomatous 6 cases. Only 2 patients had additional serologic tests. None of the patients with isolated gynecologic vasculitis received corticosteroids or additional treatment related to the vasculitis. None of the patients developed systemic vasculitis at follow-up (2 months-19.5 years; mean, 5.5 years). Isolated gynecologic vasculitis diagnosed on pathology slides is rarely associated with systemic vasculitis. Potential isolated gynecologic vasculitis causes include: previous surgical interventions and vascular inflammation secondary to local neoplasm. In almost all cases, clinicians did not perform a thorough laboratory analysis to exclude systemic vasculitis and therapy was not required in any case, suggesting minimal clinical significance.",
keywords = "Gynecological vasculitis, Isolated vasculitis, Systemic vasculitis, Vasculitides, Vasculitis",
author = "Roma, {Andres A.} and Catalina Amador-Ortiz and Helen Liapis",
year = "2014",
month = "8",
doi = "10.1016/j.anndiagpath.2014.03.008",
language = "English (US)",
volume = "18",
pages = "199--202",
journal = "Annals of Diagnostic Pathology",
issn = "1092-9134",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Significance of isolated vasculitis in the gynecological tract

T2 - What clinicians do with the pathologic diagnosis of vasculitis?

AU - Roma, Andres A.

AU - Amador-Ortiz, Catalina

AU - Liapis, Helen

PY - 2014/8

Y1 - 2014/8

N2 - Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little known. We performed a 20 year retrospective review including 53 cases with vasculitis diagnosis affecting the female genital tract identified in pathology reports. None had prior symptoms or were diagnosed with generalized vasculitis, while one patient had prior diagnosis of fibromyalgia. Most patients presented with abnormal bleeding and were treated for conditions unrelated to vasculitis. The different types of vasculitis were: predominantly lymphocytic (nonspecific) 30 cases, necrotizing 17 cases and granulomatous 6 cases. Only 2 patients had additional serologic tests. None of the patients with isolated gynecologic vasculitis received corticosteroids or additional treatment related to the vasculitis. None of the patients developed systemic vasculitis at follow-up (2 months-19.5 years; mean, 5.5 years). Isolated gynecologic vasculitis diagnosed on pathology slides is rarely associated with systemic vasculitis. Potential isolated gynecologic vasculitis causes include: previous surgical interventions and vascular inflammation secondary to local neoplasm. In almost all cases, clinicians did not perform a thorough laboratory analysis to exclude systemic vasculitis and therapy was not required in any case, suggesting minimal clinical significance.

AB - Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little known. We performed a 20 year retrospective review including 53 cases with vasculitis diagnosis affecting the female genital tract identified in pathology reports. None had prior symptoms or were diagnosed with generalized vasculitis, while one patient had prior diagnosis of fibromyalgia. Most patients presented with abnormal bleeding and were treated for conditions unrelated to vasculitis. The different types of vasculitis were: predominantly lymphocytic (nonspecific) 30 cases, necrotizing 17 cases and granulomatous 6 cases. Only 2 patients had additional serologic tests. None of the patients with isolated gynecologic vasculitis received corticosteroids or additional treatment related to the vasculitis. None of the patients developed systemic vasculitis at follow-up (2 months-19.5 years; mean, 5.5 years). Isolated gynecologic vasculitis diagnosed on pathology slides is rarely associated with systemic vasculitis. Potential isolated gynecologic vasculitis causes include: previous surgical interventions and vascular inflammation secondary to local neoplasm. In almost all cases, clinicians did not perform a thorough laboratory analysis to exclude systemic vasculitis and therapy was not required in any case, suggesting minimal clinical significance.

KW - Gynecological vasculitis

KW - Isolated vasculitis

KW - Systemic vasculitis

KW - Vasculitides

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=84904163113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904163113&partnerID=8YFLogxK

U2 - 10.1016/j.anndiagpath.2014.03.008

DO - 10.1016/j.anndiagpath.2014.03.008

M3 - Article

C2 - 24846840

AN - SCOPUS:84904163113

VL - 18

SP - 199

EP - 202

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

SN - 1092-9134

IS - 4

ER -