Significance of extra copies of chromosome 20 and the long arm of chromosome 2 in hepatoblastoma

Sarah Swarts, James Lowell Wisecarver, Julia A. Bridge

Research output: Contribution to journalArticle

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Abstract

Cytogenetic analysis of both primary and metastatic hepatoblastoma revealed the following abnormal chromosomal complements respectively: 46,XX,der(2)t(2;2)(p25;q21),der(22)t(1;22)(q22;p13)[6]/47,XX,der(2)t(2;2)(p25 ;q21),+20,der(22)t(1;22)q22;p13)[4]/47,XX,der(2)t(2;2)(p25;q21),+20[1], and 48,XX,der(2)t(2;2)(p25;q21),+12,+17,- 18,+20,der(22)t(1;22)(q22;p13)[9]/50,XX,der(2)t(2;2)(p25;q21),+8,+12,+17,+20[ 4]. Two abnormalities, the chromosome 2 derivative and trisomy 20, are recurrent in hepatoblastoma, but the derivative involving chromosomes 1 and 22 is a novel abnormality.

Original languageEnglish (US)
Pages (from-to)65-67
Number of pages3
JournalCancer genetics and cytogenetics
Volume91
Issue number1
DOIs
StatePublished - Oct 1 1996

Fingerprint

Chromosomes, Human, Pair 20
Hepatoblastoma
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Trisomy Chromosome 20

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Significance of extra copies of chromosome 20 and the long arm of chromosome 2 in hepatoblastoma. / Swarts, Sarah; Wisecarver, James Lowell; Bridge, Julia A.

In: Cancer genetics and cytogenetics, Vol. 91, No. 1, 01.10.1996, p. 65-67.

Research output: Contribution to journalArticle

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abstract = "Cytogenetic analysis of both primary and metastatic hepatoblastoma revealed the following abnormal chromosomal complements respectively: 46,XX,der(2)t(2;2)(p25;q21),der(22)t(1;22)(q22;p13)[6]/47,XX,der(2)t(2;2)(p25 ;q21),+20,der(22)t(1;22)q22;p13)[4]/47,XX,der(2)t(2;2)(p25;q21),+20[1], and 48,XX,der(2)t(2;2)(p25;q21),+12,+17,- 18,+20,der(22)t(1;22)(q22;p13)[9]/50,XX,der(2)t(2;2)(p25;q21),+8,+12,+17,+20[ 4]. Two abnormalities, the chromosome 2 derivative and trisomy 20, are recurrent in hepatoblastoma, but the derivative involving chromosomes 1 and 22 is a novel abnormality.",
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N2 - Cytogenetic analysis of both primary and metastatic hepatoblastoma revealed the following abnormal chromosomal complements respectively: 46,XX,der(2)t(2;2)(p25;q21),der(22)t(1;22)(q22;p13)[6]/47,XX,der(2)t(2;2)(p25 ;q21),+20,der(22)t(1;22)q22;p13)[4]/47,XX,der(2)t(2;2)(p25;q21),+20[1], and 48,XX,der(2)t(2;2)(p25;q21),+12,+17,- 18,+20,der(22)t(1;22)(q22;p13)[9]/50,XX,der(2)t(2;2)(p25;q21),+8,+12,+17,+20[ 4]. Two abnormalities, the chromosome 2 derivative and trisomy 20, are recurrent in hepatoblastoma, but the derivative involving chromosomes 1 and 22 is a novel abnormality.

AB - Cytogenetic analysis of both primary and metastatic hepatoblastoma revealed the following abnormal chromosomal complements respectively: 46,XX,der(2)t(2;2)(p25;q21),der(22)t(1;22)(q22;p13)[6]/47,XX,der(2)t(2;2)(p25 ;q21),+20,der(22)t(1;22)q22;p13)[4]/47,XX,der(2)t(2;2)(p25;q21),+20[1], and 48,XX,der(2)t(2;2)(p25;q21),+12,+17,- 18,+20,der(22)t(1;22)(q22;p13)[9]/50,XX,der(2)t(2;2)(p25;q21),+8,+12,+17,+20[ 4]. Two abnormalities, the chromosome 2 derivative and trisomy 20, are recurrent in hepatoblastoma, but the derivative involving chromosomes 1 and 22 is a novel abnormality.

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