Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma

Sarah J. Swarts, James R. Neff, Sonny L. Johansson, Mari Nelson, Julia A. Bridge

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Tumor specific chromosomal abnormalities have been identified in several histologic subtypes of benign and malignant bone tumors. These anomalies have proven to be useful diagnostically, Characterization of recurrent chromosomal abnormalities also has provided direction for molecular investigations of pathogenetically important genes. Cytogenetic reports of chondroblastoma, a rare benign bone tumor, are few. Cytogenetic analysis of a benign and a malignant chondroblastoma in this study revealed the following abnormal chromosomal complements: 47,XY,+5,t(5;5)(p10;q10) and 45,XY,del(2)(p23),del(3)(q23q27),dup(8)(q12q21.), del(11) (q14q23), -13, add (17) (q25) x 2, respectively. Although a specific chromosomal abnormality has not yet emerged for chondroblastoma, abnormalities of chromosomes 5 and 8 have been reported previously in this neoplasm, suggesting preferential involvement of these two chromosomes.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalClinical Orthopaedics and Related Research
Issue number349
DOIs
StatePublished - Apr 1998

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Chondroblastoma
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 5
Chromosome Aberrations
Neoplasms
Bone and Bones
Cytogenetic Analysis
Cytogenetics
Chromosomes
Genes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. / Swarts, Sarah J.; Neff, James R.; Johansson, Sonny L.; Nelson, Mari; Bridge, Julia A.

In: Clinical Orthopaedics and Related Research, No. 349, 04.1998, p. 189-193.

Research output: Contribution to journalArticle

Swarts, Sarah J. ; Neff, James R. ; Johansson, Sonny L. ; Nelson, Mari ; Bridge, Julia A. / Significance of abnormalities of chromosomes 5 and 8 in chondroblastoma. In: Clinical Orthopaedics and Related Research. 1998 ; No. 349. pp. 189-193.
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