Sickle-cell disease in Nigerian Children: Parental knowledge and laboratory results

Stephen K Obaro, Yvonne Daniel, Juliana O. Lawson, Wei Wei Hsu, John Dada, Uduak Essen, Khalid Ibrahim, Adebayo Akindele, Kevin Brooks, Grace Olanipekun, Theresa Ajose, Claire E. Stewart, Baba P D Inusa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Sickle-cell disease (SCD) is the most common inherited genetic disorder in sub-Saharan Africa, and it is associated with early mortality and lifelong morbidity. Early diagnosis is essential for instituting appropriate care and preventive therapy. Objective: To compare parental knowledge or perception of their offspring's hemoglobin phenotype prior to testing and actual validated laboratory test results. Methods: In a prospective community-based survey, we assessed parental knowledge of their children's hemoglobin phenotype and corroborated this with the results from a laboratory confirmatory test determined by high-performance liquid chromatography. Results: We screened 10,126 children aged less than 5 years. A total of 163 (1.6%) parents indicated that their offspring had been previously tested and had knowledge of the child's hemoglobin genotype. However, 51 (31.2%) of 163 parents of children who had been previously tested did not know the result of their offspring's test, and 18 (35.3%) of these 51 children were found to have SCD. Of those who claimed previous knowledge, 25 (15.3%) of 163 reported incorrect results. Overall, we identified 272 (2.76%) new cases from 9,963 children who had not been previously tested. Conclusion: There is the need to promote public awareness about SCD and the benefit of early diagnosis, quality assurance in laboratory diagnosis and institution of sustainable patient care pathways.

Original languageEnglish (US)
Pages (from-to)102-107
Number of pages6
JournalPublic Health Genomics
Volume19
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Sickle Cell Anemia
Hemoglobins
Early Diagnosis
Parents
Phenotype
Inborn Genetic Diseases
Preventive Medicine
Africa South of the Sahara
Clinical Laboratory Techniques
Knowledge of Results (Psychology)
Patient Care
Genotype
High Pressure Liquid Chromatography
Morbidity
Mortality

Keywords

  • Epidemiology
  • Nigeria
  • Parental education
  • Sickle-cell disease

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Genetics(clinical)

Cite this

Obaro, S. K., Daniel, Y., Lawson, J. O., Hsu, W. W., Dada, J., Essen, U., ... Inusa, B. P. D. (2016). Sickle-cell disease in Nigerian Children: Parental knowledge and laboratory results. Public Health Genomics, 19(2), 102-107. https://doi.org/10.1159/000444475

Sickle-cell disease in Nigerian Children : Parental knowledge and laboratory results. / Obaro, Stephen K; Daniel, Yvonne; Lawson, Juliana O.; Hsu, Wei Wei; Dada, John; Essen, Uduak; Ibrahim, Khalid; Akindele, Adebayo; Brooks, Kevin; Olanipekun, Grace; Ajose, Theresa; Stewart, Claire E.; Inusa, Baba P D.

In: Public Health Genomics, Vol. 19, No. 2, 01.04.2016, p. 102-107.

Research output: Contribution to journalArticle

Obaro, SK, Daniel, Y, Lawson, JO, Hsu, WW, Dada, J, Essen, U, Ibrahim, K, Akindele, A, Brooks, K, Olanipekun, G, Ajose, T, Stewart, CE & Inusa, BPD 2016, 'Sickle-cell disease in Nigerian Children: Parental knowledge and laboratory results', Public Health Genomics, vol. 19, no. 2, pp. 102-107. https://doi.org/10.1159/000444475
Obaro, Stephen K ; Daniel, Yvonne ; Lawson, Juliana O. ; Hsu, Wei Wei ; Dada, John ; Essen, Uduak ; Ibrahim, Khalid ; Akindele, Adebayo ; Brooks, Kevin ; Olanipekun, Grace ; Ajose, Theresa ; Stewart, Claire E. ; Inusa, Baba P D. / Sickle-cell disease in Nigerian Children : Parental knowledge and laboratory results. In: Public Health Genomics. 2016 ; Vol. 19, No. 2. pp. 102-107.
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