Sialadenosis

A presenting sign in bulimia

Hedley Coleman, Mario Altini, Simon Nayler, Alan T Richards

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: Sialadenosis refers to noninflammatory, often recurrent, enlargement of the salivary glands, most frequently the parotids, which is almost always associated with an underlying systemic disorder. These include diabetes, alcoholism, malnutrition, anorexia nervosa, and bulimia. It is thought that the various causes of sialadenosis all result in a common pathogenetic effect in that they produce a peripheral autonomic neuropathy which is responsible for disordered metabolism and secretion, resulting in acinar enlargement. Methods: This paper reports a case of sialadenosis as a presenting sign in bulimia and studies the histologic and electron microscopic features of this disease. Results: Light microscopy showed acini which appeared to be larger than normal and which were composed of plump pyramidal cells containing prominent zymogen granules. There was less interstitial fat, and the ducts were widely dispersed. Electron microscopy showed the acinar cells to be packed with membrane-limited, dark secretory granules some of which showed moulding of their outlines. Cellular organelles and nuclei were inconspicuous. Conclusions: Management of sialadenosis depends upon identification of the underlying cause, which must then be corrected. In bulimia, the swellings may be refractory to standard treatment modalities, and parotidectomy may be considered as a last resort to improve the unacceptable aesthetics.

Original languageEnglish (US)
Pages (from-to)758-762
Number of pages5
JournalHead and Neck
Volume20
Issue number8
DOIs
StatePublished - Dec 1 1998

Fingerprint

Bulimia
Secretory Vesicles
Acinar Cells
Pyramidal Cells
Anorexia Nervosa
Peripheral Nervous System Diseases
Salivary Glands
Esthetics
Malnutrition
Organelles
Alcoholism
Microscopy
Electron Microscopy
Fats
Electrons
Light
Membranes

Keywords

  • Bulimia
  • Parotid enlargement
  • Sialadenosis
  • Sialosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Sialadenosis : A presenting sign in bulimia. / Coleman, Hedley; Altini, Mario; Nayler, Simon; Richards, Alan T.

In: Head and Neck, Vol. 20, No. 8, 01.12.1998, p. 758-762.

Research output: Contribution to journalArticle

Coleman, H, Altini, M, Nayler, S & Richards, AT 1998, 'Sialadenosis: A presenting sign in bulimia', Head and Neck, vol. 20, no. 8, pp. 758-762. https://doi.org/10.1002/(SICI)1097-0347(199812)20:8<758::AID-HED16>3.0.CO;2-N
Coleman, Hedley ; Altini, Mario ; Nayler, Simon ; Richards, Alan T. / Sialadenosis : A presenting sign in bulimia. In: Head and Neck. 1998 ; Vol. 20, No. 8. pp. 758-762.
@article{64a427303e8047719610eface3db6dd1,
title = "Sialadenosis: A presenting sign in bulimia",
abstract = "Background: Sialadenosis refers to noninflammatory, often recurrent, enlargement of the salivary glands, most frequently the parotids, which is almost always associated with an underlying systemic disorder. These include diabetes, alcoholism, malnutrition, anorexia nervosa, and bulimia. It is thought that the various causes of sialadenosis all result in a common pathogenetic effect in that they produce a peripheral autonomic neuropathy which is responsible for disordered metabolism and secretion, resulting in acinar enlargement. Methods: This paper reports a case of sialadenosis as a presenting sign in bulimia and studies the histologic and electron microscopic features of this disease. Results: Light microscopy showed acini which appeared to be larger than normal and which were composed of plump pyramidal cells containing prominent zymogen granules. There was less interstitial fat, and the ducts were widely dispersed. Electron microscopy showed the acinar cells to be packed with membrane-limited, dark secretory granules some of which showed moulding of their outlines. Cellular organelles and nuclei were inconspicuous. Conclusions: Management of sialadenosis depends upon identification of the underlying cause, which must then be corrected. In bulimia, the swellings may be refractory to standard treatment modalities, and parotidectomy may be considered as a last resort to improve the unacceptable aesthetics.",
keywords = "Bulimia, Parotid enlargement, Sialadenosis, Sialosis",
author = "Hedley Coleman and Mario Altini and Simon Nayler and Richards, {Alan T}",
year = "1998",
month = "12",
day = "1",
doi = "10.1002/(SICI)1097-0347(199812)20:8<758::AID-HED16>3.0.CO;2-N",
language = "English (US)",
volume = "20",
pages = "758--762",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "8",

}

TY - JOUR

T1 - Sialadenosis

T2 - A presenting sign in bulimia

AU - Coleman, Hedley

AU - Altini, Mario

AU - Nayler, Simon

AU - Richards, Alan T

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Background: Sialadenosis refers to noninflammatory, often recurrent, enlargement of the salivary glands, most frequently the parotids, which is almost always associated with an underlying systemic disorder. These include diabetes, alcoholism, malnutrition, anorexia nervosa, and bulimia. It is thought that the various causes of sialadenosis all result in a common pathogenetic effect in that they produce a peripheral autonomic neuropathy which is responsible for disordered metabolism and secretion, resulting in acinar enlargement. Methods: This paper reports a case of sialadenosis as a presenting sign in bulimia and studies the histologic and electron microscopic features of this disease. Results: Light microscopy showed acini which appeared to be larger than normal and which were composed of plump pyramidal cells containing prominent zymogen granules. There was less interstitial fat, and the ducts were widely dispersed. Electron microscopy showed the acinar cells to be packed with membrane-limited, dark secretory granules some of which showed moulding of their outlines. Cellular organelles and nuclei were inconspicuous. Conclusions: Management of sialadenosis depends upon identification of the underlying cause, which must then be corrected. In bulimia, the swellings may be refractory to standard treatment modalities, and parotidectomy may be considered as a last resort to improve the unacceptable aesthetics.

AB - Background: Sialadenosis refers to noninflammatory, often recurrent, enlargement of the salivary glands, most frequently the parotids, which is almost always associated with an underlying systemic disorder. These include diabetes, alcoholism, malnutrition, anorexia nervosa, and bulimia. It is thought that the various causes of sialadenosis all result in a common pathogenetic effect in that they produce a peripheral autonomic neuropathy which is responsible for disordered metabolism and secretion, resulting in acinar enlargement. Methods: This paper reports a case of sialadenosis as a presenting sign in bulimia and studies the histologic and electron microscopic features of this disease. Results: Light microscopy showed acini which appeared to be larger than normal and which were composed of plump pyramidal cells containing prominent zymogen granules. There was less interstitial fat, and the ducts were widely dispersed. Electron microscopy showed the acinar cells to be packed with membrane-limited, dark secretory granules some of which showed moulding of their outlines. Cellular organelles and nuclei were inconspicuous. Conclusions: Management of sialadenosis depends upon identification of the underlying cause, which must then be corrected. In bulimia, the swellings may be refractory to standard treatment modalities, and parotidectomy may be considered as a last resort to improve the unacceptable aesthetics.

KW - Bulimia

KW - Parotid enlargement

KW - Sialadenosis

KW - Sialosis

UR - http://www.scopus.com/inward/record.url?scp=0031704562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031704562&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0347(199812)20:8<758::AID-HED16>3.0.CO;2-N

DO - 10.1002/(SICI)1097-0347(199812)20:8<758::AID-HED16>3.0.CO;2-N

M3 - Article

VL - 20

SP - 758

EP - 762

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 8

ER -