Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers

S. I. Rennard, D. Daughton, J. Fujita, M. B. Oehlerking, J. R. Dobson, M. G. Stahl, R. A. Robbins, Austin Bassett Thompson

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The beneficial effect of short-term smoking reduction in reducing lower respiratory tract inflammation was assessed in 15 healthy heavy smokers. All underwent fibreoptic bronchoscopy and bronchoalveolar lavage and were then treated with at least 20 mg of nicotine gum daily. Self-reported cigarette consumption decreased from 50.7 ± 2.3 to 18.8 ± 1.5 (p < 0.001) cigarettes daily, and expired CO decreased from 48.5 ± 2.5 to 27.3 ± 2.5 ppm (p < 0.001). After two months, repeat bronchoscopy and bronchoalveolar lavage revealed that bronchial inflammation, as assessed by direct inspection, neutrophilia of bronchial lavage fluid, and the number of alveolar macrophages, the number of alveolar neutrophils and the concentration of neutrophil elastase alpha1-antiprotease complex in alveolar lavage fluid, had improved significantly. The present study suggests that smoking reduction may be associated with an improvement in lower respiratory tract inflammation in heavy smokers and may, if persistent, be an alternative for smokers who cannot, or do not wish, to quit.

Original languageEnglish (US)
Pages (from-to)752-759
Number of pages8
JournalEuropean Respiratory Journal
Volume3
Issue number7
StatePublished - Dec 1 1990

Fingerprint

Respiratory System
Smoking
Bronchoalveolar Lavage Fluid
Bronchoscopy
Bronchoalveolar Lavage
Inflammation
Tobacco Products
Leukocyte Elastase
Alveolar Macrophages
Carbon Monoxide
Protease Inhibitors
Nicotine
Neutrophils

Keywords

  • Airway inflammation
  • Bronchoalveolar lavage
  • Smoking reduction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers. / Rennard, S. I.; Daughton, D.; Fujita, J.; Oehlerking, M. B.; Dobson, J. R.; Stahl, M. G.; Robbins, R. A.; Thompson, Austin Bassett.

In: European Respiratory Journal, Vol. 3, No. 7, 01.12.1990, p. 752-759.

Research output: Contribution to journalArticle

Rennard, SI, Daughton, D, Fujita, J, Oehlerking, MB, Dobson, JR, Stahl, MG, Robbins, RA & Thompson, AB 1990, 'Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers', European Respiratory Journal, vol. 3, no. 7, pp. 752-759.
Rennard SI, Daughton D, Fujita J, Oehlerking MB, Dobson JR, Stahl MG et al. Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers. European Respiratory Journal. 1990 Dec 1;3(7):752-759.
Rennard, S. I. ; Daughton, D. ; Fujita, J. ; Oehlerking, M. B. ; Dobson, J. R. ; Stahl, M. G. ; Robbins, R. A. ; Thompson, Austin Bassett. / Short-term smoking reduction is associated with reduction in measures of lower respiratory tract inflammation in heavy smokers. In: European Respiratory Journal. 1990 ; Vol. 3, No. 7. pp. 752-759.
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