Short communication: Quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity

Gurudutt N Pendyala, Sunia A. Trauger, Gary Siuzdak, Howard S Fox

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antixoidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 1 2011

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ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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