Short communication

Antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia

Sandra Gonzalez, Clement Gondwe, Damien C. Tully, Veenu Minhas, Danielle Shea, Chipepo Kankasa, Tendai M'Soka, Charles Wood

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The prevalence of antiretroviral therapy (ART) resistance mutations present in HIV-1 subtype C pol and env regions of the proviral DNA was analyzed and compared from therapy-naive individuals before (Cohort A) and after (Cohort B) the availability of free ART in Zambia. Mutations present in sequences published in a previous study from Zambian ART-naive individuals infected with subtype C were analyzed using current parameters for the classification of ART drug resistance and compared with Cohorts A and B. No statistically significant differences were observed when comparing mutations present in the pol and env of these cohorts. However, an increase in the number of minor, borderline, or partial resistance mutations as well as the presence of major resistance mutations were observed in Cohort B. These results suggest there is an increasing trend of drug resistance-associated mutations that could be a result of the availability of free ART in Zambia. Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C.

Original languageEnglish (US)
Pages (from-to)795-803
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2010

Fingerprint

Zambia
HIV-1
Communication
Mutation
Drug Resistance
Therapeutics
DNA

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases
  • Medicine(all)

Cite this

Short communication : Antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia. / Gonzalez, Sandra; Gondwe, Clement; Tully, Damien C.; Minhas, Veenu; Shea, Danielle; Kankasa, Chipepo; M'Soka, Tendai; Wood, Charles.

In: AIDS Research and Human Retroviruses, Vol. 26, No. 7, 01.07.2010, p. 795-803.

Research output: Contribution to journalArticle

Gonzalez, Sandra ; Gondwe, Clement ; Tully, Damien C. ; Minhas, Veenu ; Shea, Danielle ; Kankasa, Chipepo ; M'Soka, Tendai ; Wood, Charles. / Short communication : Antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia. In: AIDS Research and Human Retroviruses. 2010 ; Vol. 26, No. 7. pp. 795-803.
@article{1b1d578c02d74c77aa3788deea26329b,
title = "Short communication: Antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia",
abstract = "The prevalence of antiretroviral therapy (ART) resistance mutations present in HIV-1 subtype C pol and env regions of the proviral DNA was analyzed and compared from therapy-naive individuals before (Cohort A) and after (Cohort B) the availability of free ART in Zambia. Mutations present in sequences published in a previous study from Zambian ART-naive individuals infected with subtype C were analyzed using current parameters for the classification of ART drug resistance and compared with Cohorts A and B. No statistically significant differences were observed when comparing mutations present in the pol and env of these cohorts. However, an increase in the number of minor, borderline, or partial resistance mutations as well as the presence of major resistance mutations were observed in Cohort B. These results suggest there is an increasing trend of drug resistance-associated mutations that could be a result of the availability of free ART in Zambia. Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C.",
author = "Sandra Gonzalez and Clement Gondwe and Tully, {Damien C.} and Veenu Minhas and Danielle Shea and Chipepo Kankasa and Tendai M'Soka and Charles Wood",
year = "2010",
month = "7",
day = "1",
doi = "10.1089/aid.2009.0181",
language = "English (US)",
volume = "26",
pages = "795--803",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Short communication

T2 - Antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia

AU - Gonzalez, Sandra

AU - Gondwe, Clement

AU - Tully, Damien C.

AU - Minhas, Veenu

AU - Shea, Danielle

AU - Kankasa, Chipepo

AU - M'Soka, Tendai

AU - Wood, Charles

PY - 2010/7/1

Y1 - 2010/7/1

N2 - The prevalence of antiretroviral therapy (ART) resistance mutations present in HIV-1 subtype C pol and env regions of the proviral DNA was analyzed and compared from therapy-naive individuals before (Cohort A) and after (Cohort B) the availability of free ART in Zambia. Mutations present in sequences published in a previous study from Zambian ART-naive individuals infected with subtype C were analyzed using current parameters for the classification of ART drug resistance and compared with Cohorts A and B. No statistically significant differences were observed when comparing mutations present in the pol and env of these cohorts. However, an increase in the number of minor, borderline, or partial resistance mutations as well as the presence of major resistance mutations were observed in Cohort B. These results suggest there is an increasing trend of drug resistance-associated mutations that could be a result of the availability of free ART in Zambia. Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C.

AB - The prevalence of antiretroviral therapy (ART) resistance mutations present in HIV-1 subtype C pol and env regions of the proviral DNA was analyzed and compared from therapy-naive individuals before (Cohort A) and after (Cohort B) the availability of free ART in Zambia. Mutations present in sequences published in a previous study from Zambian ART-naive individuals infected with subtype C were analyzed using current parameters for the classification of ART drug resistance and compared with Cohorts A and B. No statistically significant differences were observed when comparing mutations present in the pol and env of these cohorts. However, an increase in the number of minor, borderline, or partial resistance mutations as well as the presence of major resistance mutations were observed in Cohort B. These results suggest there is an increasing trend of drug resistance-associated mutations that could be a result of the availability of free ART in Zambia. Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C.

UR - http://www.scopus.com/inward/record.url?scp=77954926298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954926298&partnerID=8YFLogxK

U2 - 10.1089/aid.2009.0181

DO - 10.1089/aid.2009.0181

M3 - Article

VL - 26

SP - 795

EP - 803

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 7

ER -