Short- and long-term functional results after lung volume reduction surgery for severe emphysema

H. Teschler, Austin Bassett Thompson, G. Stamatis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Lung volume reduction surgery (LVRS) has emerged as a surgical therapeutic intervention for advanced emphysema. Designed for the relief of dyspnoea, LVRS has been demonstrated to be efficacious in a subset of carefully selected patients. Short-term improvements in dyspnoea are accompanied by improvements in forced expiratory volume in one second ranging 13-96%. Lung volumes likewise improve, with lessening of trapped gas, residual volume, and total lung capacity. Improvements in functional status and quality-of-life measures parallel the improvements in dyspnoea and lung function. One preliminary study suggests that life expectancy after 3 yrs may be improved following LVRS. Many questions regarding lung volume reduction surgery in terms of operative technique, selection of patients, and outcome remain to be answered. Data are available which begin to address some of these issues. Bilateral procedures have greater short-term improvements than unilateral procedures, but the rate of loss of function following the surgery may also be greater. Stapled resection of lung tissue has been demonstrated to be superior to laser ablation. In a majority of reports, outcome is superior in patients with heterogeneous distribution of their emphysema, and patients with α1-proteinase inhibitor deficiency emphysema do less well than patients with smoker's emphysema.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalEuropean Respiratory Journal
Volume13
Issue number5
DOIs
StatePublished - Jul 1 1999

Fingerprint

Pneumonectomy
Emphysema
Dyspnea
Lung
Total Lung Capacity
Residual Volume
Forced Expiratory Volume
Laser Therapy
Life Expectancy
Patient Selection
Peptide Hydrolases
Gases
Quality of Life

Keywords

  • Emphysema
  • Lung volume reduction surgery
  • Outcome
  • Results

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Short- and long-term functional results after lung volume reduction surgery for severe emphysema. / Teschler, H.; Thompson, Austin Bassett; Stamatis, G.

In: European Respiratory Journal, Vol. 13, No. 5, 01.07.1999, p. 1170-1176.

Research output: Contribution to journalArticle

@article{ba011ec3a917440a9f07c8b91abce521,
title = "Short- and long-term functional results after lung volume reduction surgery for severe emphysema",
abstract = "Lung volume reduction surgery (LVRS) has emerged as a surgical therapeutic intervention for advanced emphysema. Designed for the relief of dyspnoea, LVRS has been demonstrated to be efficacious in a subset of carefully selected patients. Short-term improvements in dyspnoea are accompanied by improvements in forced expiratory volume in one second ranging 13-96{\%}. Lung volumes likewise improve, with lessening of trapped gas, residual volume, and total lung capacity. Improvements in functional status and quality-of-life measures parallel the improvements in dyspnoea and lung function. One preliminary study suggests that life expectancy after 3 yrs may be improved following LVRS. Many questions regarding lung volume reduction surgery in terms of operative technique, selection of patients, and outcome remain to be answered. Data are available which begin to address some of these issues. Bilateral procedures have greater short-term improvements than unilateral procedures, but the rate of loss of function following the surgery may also be greater. Stapled resection of lung tissue has been demonstrated to be superior to laser ablation. In a majority of reports, outcome is superior in patients with heterogeneous distribution of their emphysema, and patients with α1-proteinase inhibitor deficiency emphysema do less well than patients with smoker's emphysema.",
keywords = "Emphysema, Lung volume reduction surgery, Outcome, Results",
author = "H. Teschler and Thompson, {Austin Bassett} and G. Stamatis",
year = "1999",
month = "7",
day = "1",
doi = "10.1034/j.1399-3003.1999.13e38.x",
language = "English (US)",
volume = "13",
pages = "1170--1176",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

TY - JOUR

T1 - Short- and long-term functional results after lung volume reduction surgery for severe emphysema

AU - Teschler, H.

AU - Thompson, Austin Bassett

AU - Stamatis, G.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Lung volume reduction surgery (LVRS) has emerged as a surgical therapeutic intervention for advanced emphysema. Designed for the relief of dyspnoea, LVRS has been demonstrated to be efficacious in a subset of carefully selected patients. Short-term improvements in dyspnoea are accompanied by improvements in forced expiratory volume in one second ranging 13-96%. Lung volumes likewise improve, with lessening of trapped gas, residual volume, and total lung capacity. Improvements in functional status and quality-of-life measures parallel the improvements in dyspnoea and lung function. One preliminary study suggests that life expectancy after 3 yrs may be improved following LVRS. Many questions regarding lung volume reduction surgery in terms of operative technique, selection of patients, and outcome remain to be answered. Data are available which begin to address some of these issues. Bilateral procedures have greater short-term improvements than unilateral procedures, but the rate of loss of function following the surgery may also be greater. Stapled resection of lung tissue has been demonstrated to be superior to laser ablation. In a majority of reports, outcome is superior in patients with heterogeneous distribution of their emphysema, and patients with α1-proteinase inhibitor deficiency emphysema do less well than patients with smoker's emphysema.

AB - Lung volume reduction surgery (LVRS) has emerged as a surgical therapeutic intervention for advanced emphysema. Designed for the relief of dyspnoea, LVRS has been demonstrated to be efficacious in a subset of carefully selected patients. Short-term improvements in dyspnoea are accompanied by improvements in forced expiratory volume in one second ranging 13-96%. Lung volumes likewise improve, with lessening of trapped gas, residual volume, and total lung capacity. Improvements in functional status and quality-of-life measures parallel the improvements in dyspnoea and lung function. One preliminary study suggests that life expectancy after 3 yrs may be improved following LVRS. Many questions regarding lung volume reduction surgery in terms of operative technique, selection of patients, and outcome remain to be answered. Data are available which begin to address some of these issues. Bilateral procedures have greater short-term improvements than unilateral procedures, but the rate of loss of function following the surgery may also be greater. Stapled resection of lung tissue has been demonstrated to be superior to laser ablation. In a majority of reports, outcome is superior in patients with heterogeneous distribution of their emphysema, and patients with α1-proteinase inhibitor deficiency emphysema do less well than patients with smoker's emphysema.

KW - Emphysema

KW - Lung volume reduction surgery

KW - Outcome

KW - Results

UR - http://www.scopus.com/inward/record.url?scp=0033036404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033036404&partnerID=8YFLogxK

U2 - 10.1034/j.1399-3003.1999.13e38.x

DO - 10.1034/j.1399-3003.1999.13e38.x

M3 - Article

C2 - 10414422

AN - SCOPUS:0033036404

VL - 13

SP - 1170

EP - 1176

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

ER -