Sheep Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins

Marius C Florescu, Kirk W Foster, Andrew R. Sacks, John Lof, Elizabeth A. Stolze, Gretchen M. Fry, Derek P. Bumgardner, Tara Tysinger, Melanie J. Kuchta, Henry J. Runge, William B. Hadley, Michael C. Morris

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Current models of animal arteriovenous fistula (AVF) are swine models of femoral vein terminolaterally anastomosed to femoral artery, creating a deep AVF. This feature sets it aside from human AVFs using superficial veins. Our AVF model uses sheep superficial veins to create an AVF almost identical to human model. AVFs were created in six sheep using basilic veins sutured terminolaterally to brachial artery. Presurgery vein and artery diameters were measured. We measured AVFs and feeding arteries blood flows and diameters at 1, 3, and 5 weeks postsurgery. At 5 weeks we performed angiograms, euthanized animals, and harvested AVFs. Four animals completed the study. Three AVFs developed and were patent at 5 weeks; one thrombosed. Animal weight and presurgery vessels diameters predicted AVFs blood flows and diameters. Despite using vessels with diameters smaller than the ones recommended for human AVF, the Fistulas developed. Two animals died before the study conclusion for causes unrelated to surgery. This AVF model is anatomically almost identical to the human AVF and has a good maturation rate. It is a viable model for studying AVF maturation, devices intended to improve AVF maturation, AVF related procedures and can even support hemodialysis needles.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalSeminars in Dialysis
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2015

Fingerprint

Arteriovenous Fistula
Renal Dialysis
Veins
Sheep
Arteries
Femoral Vein
Brachial Artery
Femoral Artery
Fistula
Needles
Angiography
Thrombosis
Swine
Animal Models
Weights and Measures
Equipment and Supplies

ASJC Scopus subject areas

  • Nephrology

Cite this

Sheep Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins. / Florescu, Marius C; Foster, Kirk W; Sacks, Andrew R.; Lof, John; Stolze, Elizabeth A.; Fry, Gretchen M.; Bumgardner, Derek P.; Tysinger, Tara; Kuchta, Melanie J.; Runge, Henry J.; Hadley, William B.; Morris, Michael C.

In: Seminars in Dialysis, Vol. 28, No. 6, 01.11.2015, p. 687-691.

Research output: Contribution to journalArticle

Florescu, MC, Foster, KW, Sacks, AR, Lof, J, Stolze, EA, Fry, GM, Bumgardner, DP, Tysinger, T, Kuchta, MJ, Runge, HJ, Hadley, WB & Morris, MC 2015, 'Sheep Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins', Seminars in Dialysis, vol. 28, no. 6, pp. 687-691. https://doi.org/10.1111/sdi.12407
Florescu, Marius C ; Foster, Kirk W ; Sacks, Andrew R. ; Lof, John ; Stolze, Elizabeth A. ; Fry, Gretchen M. ; Bumgardner, Derek P. ; Tysinger, Tara ; Kuchta, Melanie J. ; Runge, Henry J. ; Hadley, William B. ; Morris, Michael C. / Sheep Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins. In: Seminars in Dialysis. 2015 ; Vol. 28, No. 6. pp. 687-691.
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