Sexual and social stimuli elicit rapid and contrasting genomic responses

Molly E. Cummings, Jonah Larkins-Ford, Christian R.L. Reilly, Ryan Y. Wong, Mary Ramsey, Hans A. Hofmann

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Sensory physiology has been shown to influence female mate choice, yet little is known about the mechanisms within the brain that regulate this critical behaviour. Here we examine preference behaviour of 58 female swordtails, Xiphophorus nigrensis, in four different social environments (attractive and unattractive males, females only, non-attractive males only and asocial conditions) followed by neural gene expression profiling. We used a brain-specific cDNA microarray to identify patterns of genomic response and candidate genes, followed by quantitative PCR (qPCR) examination of gene expression with variation in behaviour. Our microarray results revealed patterns of genomic response differing more between classes of social stimuli than between presence versus absence of stimuli. We identified suites of genes showing diametrically opposed patterns of expression: genes that are turned 'on' while females interact with attractive males are turned 'off' when interacting with other females, and vice versa. Our qPCR results identified significant predictive relationships between five candidate genes and specific mate choice behaviours (preference and receptivity) across females exposed to males, with no significant patterns identified in female or asocial conditions or with overall locomotor activity. The identification of stimulus- and behaviour-specific responses opens an exciting window into the molecular pathways associated with social behaviour and mechanisms that underlie sexual selection.

Original languageEnglish (US)
Pages (from-to)393-402
Number of pages10
JournalProceedings of the Royal Society B: Biological Sciences
Volume275
Issue number1633
DOIs
StatePublished - Feb 22 2008

Fingerprint

Gene expression
genomics
Genes
Microarrays
Brain
preference behavior
gene expression
Physiology
mate choice
mating behavior
Complementary DNA
brain
gene
quantitative polymerase chain reaction
Cyprinodontiformes
Choice Behavior
Gene Expression
Xiphophorus
Polymerase Chain Reaction
social environment

Keywords

  • Behavioural genomics
  • Female preference
  • Mate choice
  • Neural response

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Sexual and social stimuli elicit rapid and contrasting genomic responses. / Cummings, Molly E.; Larkins-Ford, Jonah; Reilly, Christian R.L.; Wong, Ryan Y.; Ramsey, Mary; Hofmann, Hans A.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 275, No. 1633, 22.02.2008, p. 393-402.

Research output: Contribution to journalArticle

Cummings, Molly E. ; Larkins-Ford, Jonah ; Reilly, Christian R.L. ; Wong, Ryan Y. ; Ramsey, Mary ; Hofmann, Hans A. / Sexual and social stimuli elicit rapid and contrasting genomic responses. In: Proceedings of the Royal Society B: Biological Sciences. 2008 ; Vol. 275, No. 1633. pp. 393-402.
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