Sex differences in formation of anti-T-cell antibodies

Elizabeth S. Raveche, Lynell W. Klassen, Alfred D. Steinberg

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A NATURALLY occurring thymocytotoxic autoantibody (NTA) has been found in significant titre early in life in NZB mice1. This antibody is present in almost all NZB mice by 3 months of age, and is associated with an age-dependent loss of T cells in these mice2-4. NTA may be responsible for an initial loss of suppressor T cells in NZB mice and thereby contribute to the development of autoimmunity. Although other mouse strains (NZW, C57BL/6J, AKR/J, BALB/cJ, and 129) may produce NTA later in life, the prevalence and titre of NTA is much lower than in NZB mice. NTA reacts with brain- and thymus-derived cells as well as thymocytes, but not B cells or non-lymphoid abdominal organs1-5. In contrast to standard anti-θ serum, NTA can combine with both Thy 1.1 (θ-AKR) and Thy 1.2 (θ-C3H)1,6. Genetic factors have been implicated in the development of autoimmunity in New Zealand mice7,8. In addition, X-linked immune response genes have been described for synthetic9 and naturally occurring10 nucleic acids. Moreover, female hybrids (NZB/NZW) develop a more severe disease than males. We therefore undertook the present study to determine the contribution of the X chromosome to the development of NTA.

Original languageEnglish (US)
Pages (from-to)415-416
Number of pages2
JournalNature
Volume263
Issue number5576
DOIs
StatePublished - Dec 1 1976

Fingerprint

Sex Characteristics
Autoantibodies
T-Lymphocytes
Inbred NZB Mouse
Antibodies
Autoimmunity
X Chromosome
Thymocytes
Thomsen-Friedenreich antibodies
New Zealand
Thymus Gland
Nucleic Acids
B-Lymphocytes
Brain
Serum
Genes

ASJC Scopus subject areas

  • General

Cite this

Sex differences in formation of anti-T-cell antibodies. / Raveche, Elizabeth S.; Klassen, Lynell W.; Steinberg, Alfred D.

In: Nature, Vol. 263, No. 5576, 01.12.1976, p. 415-416.

Research output: Contribution to journalArticle

Raveche, ES, Klassen, LW & Steinberg, AD 1976, 'Sex differences in formation of anti-T-cell antibodies', Nature, vol. 263, no. 5576, pp. 415-416. https://doi.org/10.1038/263415a0
Raveche, Elizabeth S. ; Klassen, Lynell W. ; Steinberg, Alfred D. / Sex differences in formation of anti-T-cell antibodies. In: Nature. 1976 ; Vol. 263, No. 5576. pp. 415-416.
@article{97ac7df7f39a4614a4dc4cbc27814133,
title = "Sex differences in formation of anti-T-cell antibodies",
abstract = "A NATURALLY occurring thymocytotoxic autoantibody (NTA) has been found in significant titre early in life in NZB mice1. This antibody is present in almost all NZB mice by 3 months of age, and is associated with an age-dependent loss of T cells in these mice2-4. NTA may be responsible for an initial loss of suppressor T cells in NZB mice and thereby contribute to the development of autoimmunity. Although other mouse strains (NZW, C57BL/6J, AKR/J, BALB/cJ, and 129) may produce NTA later in life, the prevalence and titre of NTA is much lower than in NZB mice. NTA reacts with brain- and thymus-derived cells as well as thymocytes, but not B cells or non-lymphoid abdominal organs1-5. In contrast to standard anti-θ serum, NTA can combine with both Thy 1.1 (θ-AKR) and Thy 1.2 (θ-C3H)1,6. Genetic factors have been implicated in the development of autoimmunity in New Zealand mice7,8. In addition, X-linked immune response genes have been described for synthetic9 and naturally occurring10 nucleic acids. Moreover, female hybrids (NZB/NZW) develop a more severe disease than males. We therefore undertook the present study to determine the contribution of the X chromosome to the development of NTA.",
author = "Raveche, {Elizabeth S.} and Klassen, {Lynell W.} and Steinberg, {Alfred D.}",
year = "1976",
month = "12",
day = "1",
doi = "10.1038/263415a0",
language = "English (US)",
volume = "263",
pages = "415--416",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5576",

}

TY - JOUR

T1 - Sex differences in formation of anti-T-cell antibodies

AU - Raveche, Elizabeth S.

AU - Klassen, Lynell W.

AU - Steinberg, Alfred D.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - A NATURALLY occurring thymocytotoxic autoantibody (NTA) has been found in significant titre early in life in NZB mice1. This antibody is present in almost all NZB mice by 3 months of age, and is associated with an age-dependent loss of T cells in these mice2-4. NTA may be responsible for an initial loss of suppressor T cells in NZB mice and thereby contribute to the development of autoimmunity. Although other mouse strains (NZW, C57BL/6J, AKR/J, BALB/cJ, and 129) may produce NTA later in life, the prevalence and titre of NTA is much lower than in NZB mice. NTA reacts with brain- and thymus-derived cells as well as thymocytes, but not B cells or non-lymphoid abdominal organs1-5. In contrast to standard anti-θ serum, NTA can combine with both Thy 1.1 (θ-AKR) and Thy 1.2 (θ-C3H)1,6. Genetic factors have been implicated in the development of autoimmunity in New Zealand mice7,8. In addition, X-linked immune response genes have been described for synthetic9 and naturally occurring10 nucleic acids. Moreover, female hybrids (NZB/NZW) develop a more severe disease than males. We therefore undertook the present study to determine the contribution of the X chromosome to the development of NTA.

AB - A NATURALLY occurring thymocytotoxic autoantibody (NTA) has been found in significant titre early in life in NZB mice1. This antibody is present in almost all NZB mice by 3 months of age, and is associated with an age-dependent loss of T cells in these mice2-4. NTA may be responsible for an initial loss of suppressor T cells in NZB mice and thereby contribute to the development of autoimmunity. Although other mouse strains (NZW, C57BL/6J, AKR/J, BALB/cJ, and 129) may produce NTA later in life, the prevalence and titre of NTA is much lower than in NZB mice. NTA reacts with brain- and thymus-derived cells as well as thymocytes, but not B cells or non-lymphoid abdominal organs1-5. In contrast to standard anti-θ serum, NTA can combine with both Thy 1.1 (θ-AKR) and Thy 1.2 (θ-C3H)1,6. Genetic factors have been implicated in the development of autoimmunity in New Zealand mice7,8. In addition, X-linked immune response genes have been described for synthetic9 and naturally occurring10 nucleic acids. Moreover, female hybrids (NZB/NZW) develop a more severe disease than males. We therefore undertook the present study to determine the contribution of the X chromosome to the development of NTA.

UR - http://www.scopus.com/inward/record.url?scp=0017097306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017097306&partnerID=8YFLogxK

U2 - 10.1038/263415a0

DO - 10.1038/263415a0

M3 - Article

C2 - 1085915

AN - SCOPUS:0017097306

VL - 263

SP - 415

EP - 416

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5576

ER -