Sex-dependent gene expression and evolution of the Drosophila transcriptome

José M. Ranz, Cristian I. Castillo-Davis, Colin D. Meiklejohn, Daniel L. Hartl

Research output: Contribution to journalArticle

454 Citations (Scopus)

Abstract

Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.

Original languageEnglish (US)
Pages (from-to)1742-1745
Number of pages4
JournalScience
Volume300
Issue number5626
DOIs
StatePublished - Jun 13 2003

Fingerprint

Transcriptome
Drosophila
Gene Expression
Genes
Sex Preselection
Drosophila melanogaster
Cluster Analysis
Messenger RNA

ASJC Scopus subject areas

  • General

Cite this

Sex-dependent gene expression and evolution of the Drosophila transcriptome. / Ranz, José M.; Castillo-Davis, Cristian I.; Meiklejohn, Colin D.; Hartl, Daniel L.

In: Science, Vol. 300, No. 5626, 13.06.2003, p. 1742-1745.

Research output: Contribution to journalArticle

Ranz, José M. ; Castillo-Davis, Cristian I. ; Meiklejohn, Colin D. ; Hartl, Daniel L. / Sex-dependent gene expression and evolution of the Drosophila transcriptome. In: Science. 2003 ; Vol. 300, No. 5626. pp. 1742-1745.
@article{07bca79b9c544a21b8452e14ef624fa7,
title = "Sex-dependent gene expression and evolution of the Drosophila transcriptome",
abstract = "Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83{\%} involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.",
author = "Ranz, {Jos{\'e} M.} and Castillo-Davis, {Cristian I.} and Meiklejohn, {Colin D.} and Hartl, {Daniel L.}",
year = "2003",
month = "6",
day = "13",
doi = "10.1126/science.1085881",
language = "English (US)",
volume = "300",
pages = "1742--1745",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5626",

}

TY - JOUR

T1 - Sex-dependent gene expression and evolution of the Drosophila transcriptome

AU - Ranz, José M.

AU - Castillo-Davis, Cristian I.

AU - Meiklejohn, Colin D.

AU - Hartl, Daniel L.

PY - 2003/6/13

Y1 - 2003/6/13

N2 - Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.

AB - Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.

UR - http://www.scopus.com/inward/record.url?scp=0037504137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037504137&partnerID=8YFLogxK

U2 - 10.1126/science.1085881

DO - 10.1126/science.1085881

M3 - Article

C2 - 12805547

AN - SCOPUS:0037504137

VL - 300

SP - 1742

EP - 1745

JO - Science

JF - Science

SN - 0036-8075

IS - 5626

ER -