Severe influenza in 33 US hospitals, 2013–2014

Complications and risk factors for death in 507 patients

Nirav S. Shah, Jared A. Greenberg, Moira C. McNulty, Kevin S. Gregg, James Riddell, Julie E. Mangino, Devin M. Weber, Courtney L. Hebert, Natalie S. Marzec, Michelle A. Barron, Fredy Chaparro-Rojas, Alejandro Restrepo, Vagish Hemmige, Kunatum Prasidthrathsint, Sandra Cobb, Loreen Herwaldt, Vanessa Raabe, Christopher R. Cannavino, Andrea Green Hines, Sara Bares & 26 others Philip B. Antiporta, Tonya Scardina, Ursula Patel, Gail Reid, Parvin Mohazabnia, Suresh Kachhdiya, Binh Minh Le, Connie J. Park, Belinda Ostrowsky, Ari Robicsek, Becky A. Smith, Jeanmarie Schied, Micah M. Bhatti, Stockton Mayer, Monica Sikka, Ivette Murphy-Aguilu, Priti Patwari, Shira R. Abeles, Francesca J. Torriani, Zainab Abbas, Sophie Toya, Katherine Doktor, Anindita Chakrabarti, Susanne Doblecki-Lewis, David J. Looney, Michael Z. David

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.

Original languageEnglish (US)
Pages (from-to)1251-1260
Number of pages10
JournalInfection Control and Hospital Epidemiology
Volume36
Issue number11
DOIs
StatePublished - Jan 1 2015

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Human Influenza
Intensive Care Units
Organ Dysfunction Scores
Mortality
Disease Management
Epidemiology
Cohort Studies
Retrospective Studies
Logistic Models
Odds Ratio
Regression Analysis
Drug Therapy
Infection
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Shah, N. S., Greenberg, J. A., McNulty, M. C., Gregg, K. S., Riddell, J., Mangino, J. E., ... David, M. Z. (2015). Severe influenza in 33 US hospitals, 2013–2014: Complications and risk factors for death in 507 patients. Infection Control and Hospital Epidemiology, 36(11), 1251-1260. https://doi.org/10.1017/ice.2015.170

Severe influenza in 33 US hospitals, 2013–2014 : Complications and risk factors for death in 507 patients. / Shah, Nirav S.; Greenberg, Jared A.; McNulty, Moira C.; Gregg, Kevin S.; Riddell, James; Mangino, Julie E.; Weber, Devin M.; Hebert, Courtney L.; Marzec, Natalie S.; Barron, Michelle A.; Chaparro-Rojas, Fredy; Restrepo, Alejandro; Hemmige, Vagish; Prasidthrathsint, Kunatum; Cobb, Sandra; Herwaldt, Loreen; Raabe, Vanessa; Cannavino, Christopher R.; Hines, Andrea Green; Bares, Sara; Antiporta, Philip B.; Scardina, Tonya; Patel, Ursula; Reid, Gail; Mohazabnia, Parvin; Kachhdiya, Suresh; Le, Binh Minh; Park, Connie J.; Ostrowsky, Belinda; Robicsek, Ari; Smith, Becky A.; Schied, Jeanmarie; Bhatti, Micah M.; Mayer, Stockton; Sikka, Monica; Murphy-Aguilu, Ivette; Patwari, Priti; Abeles, Shira R.; Torriani, Francesca J.; Abbas, Zainab; Toya, Sophie; Doktor, Katherine; Chakrabarti, Anindita; Doblecki-Lewis, Susanne; Looney, David J.; David, Michael Z.

In: Infection Control and Hospital Epidemiology, Vol. 36, No. 11, 01.01.2015, p. 1251-1260.

Research output: Contribution to journalArticle

Shah, NS, Greenberg, JA, McNulty, MC, Gregg, KS, Riddell, J, Mangino, JE, Weber, DM, Hebert, CL, Marzec, NS, Barron, MA, Chaparro-Rojas, F, Restrepo, A, Hemmige, V, Prasidthrathsint, K, Cobb, S, Herwaldt, L, Raabe, V, Cannavino, CR, Hines, AG, Bares, S, Antiporta, PB, Scardina, T, Patel, U, Reid, G, Mohazabnia, P, Kachhdiya, S, Le, BM, Park, CJ, Ostrowsky, B, Robicsek, A, Smith, BA, Schied, J, Bhatti, MM, Mayer, S, Sikka, M, Murphy-Aguilu, I, Patwari, P, Abeles, SR, Torriani, FJ, Abbas, Z, Toya, S, Doktor, K, Chakrabarti, A, Doblecki-Lewis, S, Looney, DJ & David, MZ 2015, 'Severe influenza in 33 US hospitals, 2013–2014: Complications and risk factors for death in 507 patients', Infection Control and Hospital Epidemiology, vol. 36, no. 11, pp. 1251-1260. https://doi.org/10.1017/ice.2015.170
Shah, Nirav S. ; Greenberg, Jared A. ; McNulty, Moira C. ; Gregg, Kevin S. ; Riddell, James ; Mangino, Julie E. ; Weber, Devin M. ; Hebert, Courtney L. ; Marzec, Natalie S. ; Barron, Michelle A. ; Chaparro-Rojas, Fredy ; Restrepo, Alejandro ; Hemmige, Vagish ; Prasidthrathsint, Kunatum ; Cobb, Sandra ; Herwaldt, Loreen ; Raabe, Vanessa ; Cannavino, Christopher R. ; Hines, Andrea Green ; Bares, Sara ; Antiporta, Philip B. ; Scardina, Tonya ; Patel, Ursula ; Reid, Gail ; Mohazabnia, Parvin ; Kachhdiya, Suresh ; Le, Binh Minh ; Park, Connie J. ; Ostrowsky, Belinda ; Robicsek, Ari ; Smith, Becky A. ; Schied, Jeanmarie ; Bhatti, Micah M. ; Mayer, Stockton ; Sikka, Monica ; Murphy-Aguilu, Ivette ; Patwari, Priti ; Abeles, Shira R. ; Torriani, Francesca J. ; Abbas, Zainab ; Toya, Sophie ; Doktor, Katherine ; Chakrabarti, Anindita ; Doblecki-Lewis, Susanne ; Looney, David J. ; David, Michael Z. / Severe influenza in 33 US hospitals, 2013–2014 : Complications and risk factors for death in 507 patients. In: Infection Control and Hospital Epidemiology. 2015 ; Vol. 36, No. 11. pp. 1251-1260.
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title = "Severe influenza in 33 US hospitals, 2013–2014: Complications and risk factors for death in 507 patients",
abstract = "background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9{\%}) and 4 children (6.3{\%}) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95{\%} CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.",
author = "Shah, {Nirav S.} and Greenberg, {Jared A.} and McNulty, {Moira C.} and Gregg, {Kevin S.} and James Riddell and Mangino, {Julie E.} and Weber, {Devin M.} and Hebert, {Courtney L.} and Marzec, {Natalie S.} and Barron, {Michelle A.} and Fredy Chaparro-Rojas and Alejandro Restrepo and Vagish Hemmige and Kunatum Prasidthrathsint and Sandra Cobb and Loreen Herwaldt and Vanessa Raabe and Cannavino, {Christopher R.} and Hines, {Andrea Green} and Sara Bares and Antiporta, {Philip B.} and Tonya Scardina and Ursula Patel and Gail Reid and Parvin Mohazabnia and Suresh Kachhdiya and Le, {Binh Minh} and Park, {Connie J.} and Belinda Ostrowsky and Ari Robicsek and Smith, {Becky A.} and Jeanmarie Schied and Bhatti, {Micah M.} and Stockton Mayer and Monica Sikka and Ivette Murphy-Aguilu and Priti Patwari and Abeles, {Shira R.} and Torriani, {Francesca J.} and Zainab Abbas and Sophie Toya and Katherine Doktor and Anindita Chakrabarti and Susanne Doblecki-Lewis and Looney, {David J.} and David, {Michael Z.}",
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TY - JOUR

T1 - Severe influenza in 33 US hospitals, 2013–2014

T2 - Complications and risk factors for death in 507 patients

AU - Shah, Nirav S.

AU - Greenberg, Jared A.

AU - McNulty, Moira C.

AU - Gregg, Kevin S.

AU - Riddell, James

AU - Mangino, Julie E.

AU - Weber, Devin M.

AU - Hebert, Courtney L.

AU - Marzec, Natalie S.

AU - Barron, Michelle A.

AU - Chaparro-Rojas, Fredy

AU - Restrepo, Alejandro

AU - Hemmige, Vagish

AU - Prasidthrathsint, Kunatum

AU - Cobb, Sandra

AU - Herwaldt, Loreen

AU - Raabe, Vanessa

AU - Cannavino, Christopher R.

AU - Hines, Andrea Green

AU - Bares, Sara

AU - Antiporta, Philip B.

AU - Scardina, Tonya

AU - Patel, Ursula

AU - Reid, Gail

AU - Mohazabnia, Parvin

AU - Kachhdiya, Suresh

AU - Le, Binh Minh

AU - Park, Connie J.

AU - Ostrowsky, Belinda

AU - Robicsek, Ari

AU - Smith, Becky A.

AU - Schied, Jeanmarie

AU - Bhatti, Micah M.

AU - Mayer, Stockton

AU - Sikka, Monica

AU - Murphy-Aguilu, Ivette

AU - Patwari, Priti

AU - Abeles, Shira R.

AU - Torriani, Francesca J.

AU - Abbas, Zainab

AU - Toya, Sophie

AU - Doktor, Katherine

AU - Chakrabarti, Anindita

AU - Doblecki-Lewis, Susanne

AU - Looney, David J.

AU - David, Michael Z.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.

AB - background. Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013–2014 influenza season. Little is known about the epidemiology of severe influenza during this season. methods. A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes. results. A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4–6.9], P=.006 and 50–64 years, 2.5 [1.3–4.9], P=.007; reference age 18–49 years), male sex (1.9 [1.1–3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9–37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2–1.4], P<.001). conclusion. Risk factors for death among US patients with severe influenza during the 2013–2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.

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DO - 10.1017/ice.2015.170

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JF - Infection Control and Hospital Epidemiology

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