Severe Hyperkalemia Complicating Voriconazole Treatment in a Kidney Transplant Recipient With Histoplasmosis: A Case Report

Research output: Contribution to journalArticle

Abstract

Voriconazole is an antifungal agent that is commonly used in immunocompromised patients who develop fungal infections. We report a case of severe recurrent hyperkalemia that developed after starting voriconazole for the treatment of histoplasmosis in a kidney transplant patient who was maintained on tacrolimus-based immunosuppression. Hyperkalemia developed despite reducing the tacrolimus dose to maintain levels in a low therapeutic range. Although interactions between azoles and calcineurin inhibitors are widely recognized, this is the 1st report describing new-onset hyperkalemia following initiation of voriconazole in a kidney transplant patient receiving tacrolimus.

Original languageEnglish (US)
Pages (from-to)2372-2373
Number of pages2
JournalTransplantation Proceedings
Volume49
Issue number10
DOIs
StatePublished - Dec 2017

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Histoplasmosis
Hyperkalemia
Tacrolimus
Kidney
Transplants
Azoles
Mycoses
Antifungal Agents
Immunocompromised Host
Immunosuppression
Therapeutics
Voriconazole
Transplant Recipients

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

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abstract = "Voriconazole is an antifungal agent that is commonly used in immunocompromised patients who develop fungal infections. We report a case of severe recurrent hyperkalemia that developed after starting voriconazole for the treatment of histoplasmosis in a kidney transplant patient who was maintained on tacrolimus-based immunosuppression. Hyperkalemia developed despite reducing the tacrolimus dose to maintain levels in a low therapeutic range. Although interactions between azoles and calcineurin inhibitors are widely recognized, this is the 1st report describing new-onset hyperkalemia following initiation of voriconazole in a kidney transplant patient receiving tacrolimus.",
author = "Nazmul, {M. N.} and Miles, {Clifford D} and Westphal, {Scott G}",
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