Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy

Gregory D. Leonard, Michael R. Wagner, Mary G. Quinn, Jean L. Grem

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Oxaliplatin-based combination chemotherapy is an option for first-line therapy of metastatic colorectal cancer. It is associated with acute hyperexcitability of motor and sensory nerves, and a cumulative sensory axonal neuropathy. We describe a 56-year-old male with metastatic colorectal cancer treated with oxaliplatin and capecitabine who developed a rapidly ascending motor and sensory neuropathy, which rendered him wheelchair-bound. Heightened clinical suspicion for possible oxaliplatin-induced motor neuropathies may be warranted.

Original languageEnglish (US)
Pages (from-to)733-735
Number of pages3
JournalAnti-Cancer Drugs
Volume15
Issue number7
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

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oxaliplatin
Polyneuropathies
Drug Therapy
Colorectal Neoplasms
Wheelchairs
Combination Drug Therapy

Keywords

  • Oxaliplatin-based chemotherapy
  • Sensory-motor polyneuropathy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research

Cite this

Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy. / Leonard, Gregory D.; Wagner, Michael R.; Quinn, Mary G.; Grem, Jean L.

In: Anti-Cancer Drugs, Vol. 15, No. 7, 01.08.2004, p. 733-735.

Research output: Contribution to journalArticle

Leonard, Gregory D. ; Wagner, Michael R. ; Quinn, Mary G. ; Grem, Jean L. / Severe disabling sensory-motor polyneuropathy during oxaliplatin-based chemotherapy. In: Anti-Cancer Drugs. 2004 ; Vol. 15, No. 7. pp. 733-735.
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