Severe chronic active epstein-barr virus infection syndrome and adenovirus type-2 infection

M. Okano, Geoffrey Milton Thiele, D. T. Purtilo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Four patients from 4 to 24 years of age (3 males, 1 female) with generalized lymphadenopathy, hepatosplenomegaly, and intermittent fever associated with chronic active Epstein-Barr virus (EBV) infection were investigated. Laboratory data showed polyclonal gammopathy and a tendency for bone marrow suppression. Noteworthy were the extremely elevated immunoglobulin G (IgG) antibody titers to Epstein-Barr viral capsid antigen (VCA) (range, 10, 240-81, 920) and early antigen (EA) (range, 1, 280- 40, 960). All patients had IgA antibodies to VCA and EA. Subtle, heterogeneous immune functional defects were observed in all four patients. Another unusual feature was our inability to establish spontaneous or B95-8 EBV- immortalized lymphoblastiod cell lines (LCLs) due to a marked cytopathic effect (CPE). Thus, we investigated for other viruses. Both IgG and IgM antibodies to adenovirus type-2 (Ad-2) were positive by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence (IF) test, suggesting recent or activated Ad-2 infection had occurred. Dual active EBV and Ad-2 infections were likely etiologic in this severe chronic active EBV infection syndrome.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume12
Issue number2
StatePublished - Jan 1 1990

Fingerprint

Adenoviridae Infections
Epstein-Barr Virus Infections
Human Herpesvirus 4
Antibodies
Immunoglobulin G
Antigens
Viral Antigens
Capsid
Adenoviridae
Immunoglobulin A
Fluorescent Antibody Technique
Immunoglobulin M
Fever
Bone Marrow
Enzyme-Linked Immunosorbent Assay
Viruses
Cell Line

Keywords

  • Adenovirus
  • Barr virus (EBV) infection
  • Chronic active epstein
  • Immunodeficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Severe chronic active epstein-barr virus infection syndrome and adenovirus type-2 infection. / Okano, M.; Thiele, Geoffrey Milton; Purtilo, D. T.

In: American Journal of Pediatric Hematology/Oncology, Vol. 12, No. 2, 01.01.1990, p. 168-173.

Research output: Contribution to journalArticle

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