SET-domain proteins of the Su(var)3-9, E(z) and Trithorax families

Raul Alvarez-Venegas, Zoya V Avramova

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

SET-domain (SET: Su(var)3-9, E(z) and Trithorax)-containing proteins were collected through sequence searches of the available databases. After removing redundancies, the proteins belonging to three families, SU(VAR)3-9, E(Z) and TRITHORAX, were selected. Analysis of the relationship between the different members is based on pairwise alignment, compilation, and comparison of their SET-domains. The level of homology of the SET-domains defined the distribution of the proteins into families and into clades within the families. The architecture of the entire protein supported the distribution pattern built upon SET-domain similarity. Parallel cladistic and protein-architecture analyses outlined two plausible criteria for predicting function.

Original languageEnglish (US)
Pages (from-to)25-37
Number of pages13
JournalGene
Volume285
Issue number1-2
DOIs
StatePublished - Feb 20 2002

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Proteins
Protein Domains
Databases
SU(VAR)3-9

Keywords

  • Chromatin modifier
  • Database analysis
  • Evolution and homology of SET-domain genes

ASJC Scopus subject areas

  • Genetics

Cite this

SET-domain proteins of the Su(var)3-9, E(z) and Trithorax families. / Alvarez-Venegas, Raul; Avramova, Zoya V.

In: Gene, Vol. 285, No. 1-2, 20.02.2002, p. 25-37.

Research output: Contribution to journalReview article

Alvarez-Venegas, Raul ; Avramova, Zoya V. / SET-domain proteins of the Su(var)3-9, E(z) and Trithorax families. In: Gene. 2002 ; Vol. 285, No. 1-2. pp. 25-37.
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