Serum organochlorine pesticide levels in patients with colorectal cancer in egypt

Amr S. Soliman, Melissa L. Bondy, Mary Ann Smith, Sharon P. Cooper, R. Sue McPherson, Kadry Ismail, Ibrahim A. Seifeldin, Hussein Khaled, Sohair Ismail

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The widespread use of pesticides in Egypt, the high incidence of colorectal cancer in Egyptian children and young adults, and the published U.S. case reports in which pesticides have been connected with colorectal cancer led the authors to investigate the possible association between organochlorines and colorectal cancer. The authors conducted a pilot study to describe serum organochlorine levels among 31 Egyptian colorectal patients and 17 controls. High levels and large interindividual variability of p, p'-dichloro-diphenyl-dicholoroethylene (DDE), dichloro-diphenyl-trichloroanthane (DDT), β-hexachlorocyclohexane (β-HCH), and hexachlorobenzene (HCB) levels were found among most subjects, especially those from rural areas. Farming and aging were each associated positively with high serum organochlorines. Colorectal cancer patients had higher serum organochlorines levels than controls. The high levels of organochlorines reported and their relation to age, residence, occupation, and disease status justify further study of the possible association between organochlorine pesticides and colorectal cancer in a larger population in Egypt.

Original languageEnglish (US)
Pages (from-to)409-415
Number of pages7
JournalArchives of Environmental Health
Volume52
Issue number6
DOIs
StatePublished - Jan 1 1997

Fingerprint

Egypt
Pesticides
organochlorine
serum
Colorectal Neoplasms
cancer
Serum
Hexachlorobenzene
Lindane
Level control
pesticide
Aging of materials
hexachlorobenzene
HCH
Agriculture
Occupations
occupation
Young Adult
rural area
organochlorine pesticide

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Soliman, A. S., Bondy, M. L., Smith, M. A., Cooper, S. P., McPherson, R. S., Ismail, K., ... Ismail, S. (1997). Serum organochlorine pesticide levels in patients with colorectal cancer in egypt. Archives of Environmental Health, 52(6), 409-415. https://doi.org/10.1080/00039899709602219

Serum organochlorine pesticide levels in patients with colorectal cancer in egypt. / Soliman, Amr S.; Bondy, Melissa L.; Smith, Mary Ann; Cooper, Sharon P.; McPherson, R. Sue; Ismail, Kadry; Seifeldin, Ibrahim A.; Khaled, Hussein; Ismail, Sohair.

In: Archives of Environmental Health, Vol. 52, No. 6, 01.01.1997, p. 409-415.

Research output: Contribution to journalArticle

Soliman, AS, Bondy, ML, Smith, MA, Cooper, SP, McPherson, RS, Ismail, K, Seifeldin, IA, Khaled, H & Ismail, S 1997, 'Serum organochlorine pesticide levels in patients with colorectal cancer in egypt', Archives of Environmental Health, vol. 52, no. 6, pp. 409-415. https://doi.org/10.1080/00039899709602219
Soliman AS, Bondy ML, Smith MA, Cooper SP, McPherson RS, Ismail K et al. Serum organochlorine pesticide levels in patients with colorectal cancer in egypt. Archives of Environmental Health. 1997 Jan 1;52(6):409-415. https://doi.org/10.1080/00039899709602219
Soliman, Amr S. ; Bondy, Melissa L. ; Smith, Mary Ann ; Cooper, Sharon P. ; McPherson, R. Sue ; Ismail, Kadry ; Seifeldin, Ibrahim A. ; Khaled, Hussein ; Ismail, Sohair. / Serum organochlorine pesticide levels in patients with colorectal cancer in egypt. In: Archives of Environmental Health. 1997 ; Vol. 52, No. 6. pp. 409-415.
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