SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

P. Ferenci, G. Kleinberger, D. F. Schafer, J. H. Hoofnagle, E. A. Jones

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

Original languageEnglish (US)
Pages (from-to)811-814
Number of pages4
JournalThe Lancet
Volume322
Issue number8354
DOIs
StatePublished - Oct 8 1983

Fingerprint

gamma-Aminobutyric Acid
Chronic Disease
Biliary Liver Cirrhosis
Serum
Radioligand Assay
Chronic Hepatitis
Hepatitis
Liver Diseases
Healthy Volunteers
Fibrosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE. / Ferenci, P.; Kleinberger, G.; Schafer, D. F.; Hoofnagle, J. H.; Jones, E. A.

In: The Lancet, Vol. 322, No. 8354, 08.10.1983, p. 811-814.

Research output: Contribution to journalArticle

Ferenci, P. ; Kleinberger, G. ; Schafer, D. F. ; Hoofnagle, J. H. ; Jones, E. A. / SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE. In: The Lancet. 1983 ; Vol. 322, No. 8354. pp. 811-814.
@article{04c72d115351455b83714fd3c35ebcbb,
title = "SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE",
abstract = "Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96{\%} of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.",
author = "P. Ferenci and G. Kleinberger and Schafer, {D. F.} and Hoofnagle, {J. H.} and Jones, {E. A.}",
year = "1983",
month = "10",
day = "8",
doi = "10.1016/S0140-6736(83)90735-3",
language = "English (US)",
volume = "322",
pages = "811--814",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8354",

}

TY - JOUR

T1 - SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

AU - Ferenci, P.

AU - Kleinberger, G.

AU - Schafer, D. F.

AU - Hoofnagle, J. H.

AU - Jones, E. A.

PY - 1983/10/8

Y1 - 1983/10/8

N2 - Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

AB - Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

UR - http://www.scopus.com/inward/record.url?scp=0020604499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020604499&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(83)90735-3

DO - 10.1016/S0140-6736(83)90735-3

M3 - Article

C2 - 6137647

AN - SCOPUS:0020604499

VL - 322

SP - 811

EP - 814

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8354

ER -