SERUM LEVELS OF GAMMA-AMINOBUTYRIC-ACID-LIKE ACTIVITY IN ACUTE AND CHRONIC HEPATOCELLULAR DISEASE

P. Ferenci, G. Kleinberger, D. F. Schafer, J. H. Hoofnagle, E. A. Jones

Research output: Contribution to journalArticle

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Abstract

Serum levels of GABA (gamma-aminobutyric acid)-like activity were measured by a radioreceptor assay in 22 healthy subjects and 170 patients with liver diseases. Levels were within normal limits (mean±SEM in healthy controls 0 ·52±0·04 μmol/l; range 0·2-0·8 μmol/l GABA equivalents) in most patients with uncomplicated acute viral hepatitis, compensated chronic hepatitis, and primary biliary cirrhosis (PBC). In 96% of patients with compensated (non-PBC) cirrhosis levels were slightly high (1·5+0·06 μmol/l). In 4 patients with.

Original languageEnglish (US)
Pages (from-to)811-814
Number of pages4
JournalThe Lancet
Volume322
Issue number8354
DOIs
Publication statusPublished - Oct 8 1983

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ASJC Scopus subject areas

  • Medicine(all)

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