Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass

W. H. Fleming, L. B. Sarafian, M. P. Leuschen, M. C. Newland, E. M. Kennedy, John Dale Kugler, James William Chapin, Barbara Jean Hurlbert, David Lloyd Bolam, R. M. Nelson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Twenty-six consecutive pediatric patients undergoing reparative procedures necessitating cardiopulmonary bypass were prospectively studied to determine changes in serum levels of 6-keto-prostaglandin F(1α) and thomboxane B2. Cardiac lesions included acyanotic lesions (five patients), obstructive lesions (10 patients), and right-to-left shunts (11 patients). There was a significant (p < 0.05) increase in 6-keto-prostaglandin F(1α) from preoperative levels to levels measured at the time of arterial and venous cannula insertion. This concentration was maintained throughout cardiopulmonary bypass and remained significantly elevated (p < 0.001) in the recovery room, but returned to preoperative levels by the morning after the operation. Preoperative levels of thromboxane B2 varied widely and were not significantly different from intraoperative levels. The postoperative levels of thromboxane B2, however, were significantly different (p < 0.05) from the intraoperative levels. In the pediatric age group undergoing cardiopulmonary bypass, 6-keto-prostaglandin F(1α) and thromboxane B2 change during bypass but do not significantly differ when preoperative levels are compared to postoperative values.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume92
Issue number1
StatePublished - Sep 4 1986

Fingerprint

Thromboxane B2
Thromboxanes
Prostaglandins F
Epoprostenol
Cardiopulmonary Bypass
Serum
Pediatrics
Recovery Room
Patient Rights
Age Groups

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Fleming, W. H., Sarafian, L. B., Leuschen, M. P., Newland, M. C., Kennedy, E. M., Kugler, J. D., ... Nelson, R. M. (1986). Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery, 92(1), 73-78.

Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass. / Fleming, W. H.; Sarafian, L. B.; Leuschen, M. P.; Newland, M. C.; Kennedy, E. M.; Kugler, John Dale; Chapin, James William; Hurlbert, Barbara Jean; Bolam, David Lloyd; Nelson, R. M.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 92, No. 1, 04.09.1986, p. 73-78.

Research output: Contribution to journalArticle

Fleming, WH, Sarafian, LB, Leuschen, MP, Newland, MC, Kennedy, EM, Kugler, JD, Chapin, JW, Hurlbert, BJ, Bolam, DL & Nelson, RM 1986, 'Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass', Journal of Thoracic and Cardiovascular Surgery, vol. 92, no. 1, pp. 73-78.
Fleming, W. H. ; Sarafian, L. B. ; Leuschen, M. P. ; Newland, M. C. ; Kennedy, E. M. ; Kugler, John Dale ; Chapin, James William ; Hurlbert, Barbara Jean ; Bolam, David Lloyd ; Nelson, R. M. / Serum concentrations of prostacyclin and thromboxane in children before, during, and after cardiopulmonary bypass. In: Journal of Thoracic and Cardiovascular Surgery. 1986 ; Vol. 92, No. 1. pp. 73-78.
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