Serum Coenzyme Q10, α-Tocopherol, γ-Tocopherol, and C-Reactive Protein Levels and Body Mass Index in Adolescent and Premenopausal Females

Weiwen Chai, Rachel Novotny, Gertraud Maskarinec, Loic Le Marchand, Adrian A. Franke, Robert V. Cooney

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: Lipid-soluble antioxidants are associated with a lower incidence for many chronic diseases of aging, possibly by preventing damage from chronic inflammation. In the current study, we compared serum levels of coenzyme Q10 (CoQ10), α-tocopherol, γ-tocopherol, and C-reactive protein (CRP) between adolescent girls and premenopausal women to assess changes from childhood to midlife.Methods: Baseline serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels were measured in 207 girls (13-19 years) and 183 premenopausal women (34-47 years) using standard methods and the 2 age groups were compared by t test. The influence of age, body mass index (BMI), and race/ethnicity and interaction effects on serum values were assessed using analysis of covariance. Pearson correlation coefficients were used to assess associations between pairs of lipid micronutrients.Results: Overall, adolescent girls had significantly lower mean serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels relative to premenopausal women (CoQ10: 376 vs 544 ng/mL, p < 0.0001; α-tocopherol: 6.9 vs 13.5 μg/mL, p < 0.0001; γ-tocopherol: 1.3 vs 1.7 μg/mL, p < 0.0001; CRP: 1.29 vs 2.13 mg/L, p < 0.0001). The differences in CoQ10 and tocopherols remained significant after adjustment for BMI and race/ethnicity. CoQ10 was significantly and positively correlated to α- and γ-tocopherol, and BMI was positively associated with CRP and γ-tocopherol in both groups.Conclusions: Lower serum CoQ10, α-tocopherol, γ-tocopherol, and CRP levels in adolescent girls compared to women suggests that adolescents may have a reduced need for antioxidants possibly due to their lower BMI and inflammatory status as indicated by CRP.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
JournalJournal of the American College of Nutrition
Volume33
Issue number3
DOIs
StatePublished - May 2014

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Keywords

  • C-reactive protein
  • adolescent girls
  • body mass index
  • premenopausal women
  • tocopherols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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