Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population

Weiwen Chai, G. Maskarinec, R. V. Cooney

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH)D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH)D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH)D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH)D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH)D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways.

Original languageEnglish (US)
Pages (from-to)652-654
Number of pages3
JournalEuropean Journal of Clinical Nutrition
Volume64
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Serum
Population
Vitamin D
Body Mass Index
Breast Neoplasms
Menarche
Birth Order
Parity
25-hydroxyvitamin D
Breast Density

Keywords

  • 25-hydroxyvitamin D
  • Breast cancer
  • Mammographic density
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population. / Chai, Weiwen; Maskarinec, G.; Cooney, R. V.

In: European Journal of Clinical Nutrition, Vol. 64, No. 6, 01.06.2010, p. 652-654.

Research output: Contribution to journalArticle

@article{34ea3f26994e4124be912521070613b4,
title = "Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population",
abstract = "Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH)D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH)D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH)D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH)D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH)D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways.",
keywords = "25-hydroxyvitamin D, Breast cancer, Mammographic density, Vitamin D",
author = "Weiwen Chai and G. Maskarinec and Cooney, {R. V.}",
year = "2010",
month = "6",
day = "1",
doi = "10.1038/ejcn.2010.36",
language = "English (US)",
volume = "64",
pages = "652--654",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Serum 25-hydroxyvitamin D levels and mammographic density among premenopausal women in a multiethnic population

AU - Chai, Weiwen

AU - Maskarinec, G.

AU - Cooney, R. V.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH)D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH)D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH)D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH)D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH)D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways.

AB - Although some evidence suggests a protective role of vitamin D against breast cancer, epidemiological findings are inconsistent. The current study investigated the relation of serum 25-hydroxyvitamin D (25(OH)D) levels with mammographic density. Baseline serum samples from 182 premenopausal women including 67 Caucasians and 74 Asians from a nutritional trial were analyzed for 25(OH)D. Mammographic density was assessed using a computer-assisted method. Serum 25(OH)D was not associated with mammographic density after adjustment for confounders (body mass index (BMI), age at mammogram, Asian ethnicity, age at first birth, parity and age at menarche). 25(OH)D levels were significantly lower in Asians than in Caucasians, but no significant ethnic differences in mammographic density were observed after adjusting for BMI. Although the current results indicate that serum 25(OH)D levels were not associated with mammographic density among premenopausal women, a possible protective effect of vitamin D against breast cancer may be mediated through other pathways.

KW - 25-hydroxyvitamin D

KW - Breast cancer

KW - Mammographic density

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=77953229127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953229127&partnerID=8YFLogxK

U2 - 10.1038/ejcn.2010.36

DO - 10.1038/ejcn.2010.36

M3 - Article

VL - 64

SP - 652

EP - 654

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 6

ER -