Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism

Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder, Margit Burmeister

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Background: A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with inconclusive results. A GABA(A) receptor α6 subunit variant (Pro385Ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression. Methods: A total of 384 subjects who completed the NEO-PI were genotyped at 5-HTTLPR and Pro385Ser. Associations between polymorphisms and both alcohol use and personality domains were tested. Results: The 5-HTTLPR short allele (p = .008) and Pro385Ser Pro allele (p = .003) are associated with higher neuroticism scores. The 5-HTTLPR long allele (p = .006), but not Pro385Ser, is also associated with an increased presence of alcohol use. In addition, there is a nonsignificant suggestion of an interaction: the effect of 5-HTTLPR on neuroticism might be dependent on the Pro385Ser genotype. Conclusions: These findings support a role for the serotonin transporter and GABA(A) α6 subunit in depression-related traits.

Original languageEnglish (US)
Pages (from-to)244-249
Number of pages6
JournalBiological Psychiatry
Volume55
Issue number3
DOIs
StatePublished - Feb 1 2004

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Serotonin Plasma Membrane Transport Proteins
gamma-Aminobutyric Acid
Personality Inventory
Alleles
Alcohols
Depression
GABA-A Receptors
Neuroticism
Psychiatry
Personality
Epidemiologic Studies
Genotype

Keywords

  • Anxiety
  • Association
  • Depression
  • Interaction
  • NEO-PI
  • Personality
  • Polymorphism
  • Serotonin
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism. / Sen, Srijan; Villafuerte, Sandra; Nesse, Randolph; Stoltenberg, Scott F.; Hopcian, Jeffrey; Gleiberman, Lillian; Weder, Alan; Burmeister, Margit.

In: Biological Psychiatry, Vol. 55, No. 3, 01.02.2004, p. 244-249.

Research output: Contribution to journalArticle

Sen, S, Villafuerte, S, Nesse, R, Stoltenberg, SF, Hopcian, J, Gleiberman, L, Weder, A & Burmeister, M 2004, 'Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism', Biological Psychiatry, vol. 55, no. 3, pp. 244-249. https://doi.org/10.1016/j.biopsych.2003.08.006
Sen, Srijan ; Villafuerte, Sandra ; Nesse, Randolph ; Stoltenberg, Scott F. ; Hopcian, Jeffrey ; Gleiberman, Lillian ; Weder, Alan ; Burmeister, Margit. / Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism. In: Biological Psychiatry. 2004 ; Vol. 55, No. 3. pp. 244-249.
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