Serotonin depletion does not prevent intrinsic sensitization in the leech

Brian D Burrell, Christie L. Sahley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Intrinsic sensitization is a form of behavioral facilitation that is distinct from the extrinsic sensitization normally studied. To examine whether intrinsic and extrinsic sensitization are mediated by different physiological processes, the effects of 5,7-dihydroxytryptamine-induced serotonin (5-HT) depletion on intrinsic sensitization of the leech whole-body shortening response were observed. Previous experiments have shown that 5-HT depletion disrupts dishabituation and extrinsic sensitization of this behavior in the leech. Intrinsic sensitization was observed in preparations from both control and 5-HT-depleted animals, indicating that this form of behavioral facilitation was not affected by 5-HT depletion. The differences in the effects of 5-HT depletion on intrinsic versus extrinsic sensitization suggest that there are distinct neurophysiological processes mediating these two forms of behavioral facilitation. In addition, 5-HT depletion appeared to disrupt a putative extrinsic form of habituation of the shortening reflex. These data support the hypothesis that both intrinsic and extrinsic processes of neuromodulation mediate habituation and sensitization.

Original languageEnglish (US)
Pages (from-to)509-520
Number of pages12
JournalLearning and Memory
Volume6
Issue number5
DOIs
StatePublished - Nov 8 1999

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Leeches
Serotonin
5,7-Dihydroxytryptamine
Physiological Phenomena
Reflex

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Serotonin depletion does not prevent intrinsic sensitization in the leech. / Burrell, Brian D; Sahley, Christie L.

In: Learning and Memory, Vol. 6, No. 5, 08.11.1999, p. 509-520.

Research output: Contribution to journalArticle

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