Serotonergic responses to corticosterone and testosterone in the limbic system

Cliff H. Summers, Earl T. Larson, Patrick Ronan, Peter M. Hofmann, Aaron J. Emerson, Kenneth J. Renner

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Glucocorticoids secreted peripherally during stressful events act on central monoaminergic systems. In particular, serotonergic mediation of social behavior, such as aggression and reproduction, may be affected by glucocorticoids. This study was undertaken to determine if systemically administered corticosterone would rapidly affect central monoaminergic activity. Male Anolis carolinensis (N = 8 each group) were injected intraperitoneally with 10 or 100 μg corticosterone, 10 μg testosterone, or saline. Twenty minutes after treatment, brains were rapidly dissected and frozen and then microdissected (punch diameter 300 μm) and analyzed by high- performance liquid chromatography. Serotonergic turnover (estimated by 5- hydroxyindoleacetic acid/serotonin) in the hippocampus and medial amygdala was significantly enhanced by systemic corticosterone. Both of these regions of the brain have been associated with social stress. Testosterone also enhanced turnover in the hippocampus. The effect of corticosterone and testosterone may be to modulate socially induced differences in serotonergic response. Rapid, but short-lived, glucocorticoid stimulation of serotonin release suggests a possible mechanism for mediation of changing social behavioral events.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalGeneral and Comparative Endocrinology
Volume117
Issue number1
DOIs
StatePublished - Jan 1 2000

Fingerprint

Limbic System
corticosterone
Corticosterone
testosterone
Testosterone
glucocorticoids
Glucocorticoids
hippocampus
serotonin
Hippocampus
Serotonin
5-hydroxyindoleacetic acid
Anolis carolinensis
brain
amygdala
Hydroxyindoleacetic Acid
Social Behavior
Brain
Amygdala
Aggression

Keywords

  • Amygdala
  • Androgen
  • Anolis carolinensis
  • Brain punch
  • Glucocorticoid
  • Hippocampus
  • Lizard
  • Microdissection
  • Serotonin

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

Cite this

Serotonergic responses to corticosterone and testosterone in the limbic system. / Summers, Cliff H.; Larson, Earl T.; Ronan, Patrick; Hofmann, Peter M.; Emerson, Aaron J.; Renner, Kenneth J.

In: General and Comparative Endocrinology, Vol. 117, No. 1, 01.01.2000, p. 151-159.

Research output: Contribution to journalArticle

Summers, Cliff H. ; Larson, Earl T. ; Ronan, Patrick ; Hofmann, Peter M. ; Emerson, Aaron J. ; Renner, Kenneth J. / Serotonergic responses to corticosterone and testosterone in the limbic system. In: General and Comparative Endocrinology. 2000 ; Vol. 117, No. 1. pp. 151-159.
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