Seroprevalence of human herpesvirus 8 and hepatitis C virus among drug users in Shanghai, China

Tiejun Zhang, Ying Liu, Yuyan Zhang, Jun Wang, Veenu Minhas, Charles Wood, Na He

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5%) participants were found to be positive for HHV8 antibodies, while 271 (61.5%) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95% CI 1.41-3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95% CI 0.94-60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.

Original languageEnglish (US)
Pages (from-to)2519-2530
Number of pages12
JournalViruses
Volume6
Issue number6
DOIs
StatePublished - Jun 23 2014

Fingerprint

Human Herpesvirus 8
Seroepidemiologic Studies
Drug Users
Hepacivirus
China
Syphilis
Herpesviridae Infections
Hepatitis C Antibodies
Virus Diseases
Sexual Behavior
Pharmaceutical Preparations
Cross-Sectional Studies
History
Antibodies
Infection
Population

Keywords

  • China
  • Drug user
  • Hepatitis C virus
  • Human herpesvirus 8
  • Prevalence

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Seroprevalence of human herpesvirus 8 and hepatitis C virus among drug users in Shanghai, China. / Zhang, Tiejun; Liu, Ying; Zhang, Yuyan; Wang, Jun; Minhas, Veenu; Wood, Charles; He, Na.

In: Viruses, Vol. 6, No. 6, 23.06.2014, p. 2519-2530.

Research output: Contribution to journalArticle

Zhang, T, Liu, Y, Zhang, Y, Wang, J, Minhas, V, Wood, C & He, N 2014, 'Seroprevalence of human herpesvirus 8 and hepatitis C virus among drug users in Shanghai, China', Viruses, vol. 6, no. 6, pp. 2519-2530. https://doi.org/10.3390/v6062519
Zhang, Tiejun ; Liu, Ying ; Zhang, Yuyan ; Wang, Jun ; Minhas, Veenu ; Wood, Charles ; He, Na. / Seroprevalence of human herpesvirus 8 and hepatitis C virus among drug users in Shanghai, China. In: Viruses. 2014 ; Vol. 6, No. 6. pp. 2519-2530.
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abstract = "To elucidate and compare the seroprevalence of human herpesvirus 8 (HHV8) and hepatitis C virus (HCV) among Chinese drug users, a cross-sectional study of 441 participants, was conducted in Shanghai, China, from 2012 through 2013. Seventy-seven (17.5{\%}) participants were found to be positive for HHV8 antibodies, while 271 (61.5{\%}) participants were positive for HCV. No significant association between HHV8 seropositivity and drug use characteristics, sexual behaviors, HCV, or syphilis was observed. In contrast, a statistically significant association between HCV seropositivity and injected drug history (OR, 2.18, 95{\%} CI 1.41-3.37) was detected, whereas no statistically significant association between HCV seropositivity and syphilis infection (OR, 7.56, 95{\%} CI 0.94-60.57) were observed. Pairwise comparisons showed no significant differences between latent and lytic antibodies regarding HCV and HHV8 serostatus. The study demonstrated a moderate but elevated prevalence of HHV8 infection among drug users. The discordance between HHV8 and HCV infections suggests that blood borne transmission of HHV8 might not be the predominant mode of transmission in this population, which is in contrast to HCV.",
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