Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China

Tiejun Zhang, Zhenqiu Liu, Jun Wang, Veenu Minhas, Charles Wood, Gary M. Clifford, Na He, Silvia Franceschi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. Methods: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95% confidence interval (95% CI) for KSHV-positivity were estimated using Poisson regression. Results: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8% (95% CI: 7.9%-11.7%) in male migrants to 32.3% (95% CI: 24.1%-34.1%) in MSM. IVDU show intermediate level (17.5%, 95%CI: 14.1%-21.4%). KSHV was associated with syphilis (PR = 2.03, 95% CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95%: 1.22-2.75) but not in migrant workers or FSW. Conclusions: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10%, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals.

Original languageEnglish (US)
Article number32
JournalInfectious Agents and Cancer
Volume12
Issue number1
DOIs
StatePublished - May 30 2017

Fingerprint

Human Herpesvirus 8
Seroepidemiologic Studies
China
HIV
Antibodies
Sex Workers
Sexually Transmitted Diseases
Drug Users
Confidence Intervals
Heterosexuality
Viruses
Syphilis
Fluorescent Antibody Technique
Antigens

Keywords

  • China
  • Kaposi's sarcoma associated herpesvirus
  • Prevalence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Infectious Diseases
  • Cancer Research

Cite this

Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China. / Zhang, Tiejun; Liu, Zhenqiu; Wang, Jun; Minhas, Veenu; Wood, Charles; Clifford, Gary M.; He, Na; Franceschi, Silvia.

In: Infectious Agents and Cancer, Vol. 12, No. 1, 32, 30.05.2017.

Research output: Contribution to journalArticle

Zhang, Tiejun ; Liu, Zhenqiu ; Wang, Jun ; Minhas, Veenu ; Wood, Charles ; Clifford, Gary M. ; He, Na ; Franceschi, Silvia. / Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China. In: Infectious Agents and Cancer. 2017 ; Vol. 12, No. 1.
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abstract = "Background: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. Methods: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95{\%} confidence interval (95{\%} CI) for KSHV-positivity were estimated using Poisson regression. Results: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8{\%} (95{\%} CI: 7.9{\%}-11.7{\%}) in male migrants to 32.3{\%} (95{\%} CI: 24.1{\%}-34.1{\%}) in MSM. IVDU show intermediate level (17.5{\%}, 95{\%}CI: 14.1{\%}-21.4{\%}). KSHV was associated with syphilis (PR = 2.03, 95{\%} CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95{\%}: 1.22-2.75) but not in migrant workers or FSW. Conclusions: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10{\%}, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals.",
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T1 - Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China

AU - Zhang, Tiejun

AU - Liu, Zhenqiu

AU - Wang, Jun

AU - Minhas, Veenu

AU - Wood, Charles

AU - Clifford, Gary M.

AU - He, Na

AU - Franceschi, Silvia

PY - 2017/5/30

Y1 - 2017/5/30

N2 - Background: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. Methods: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95% confidence interval (95% CI) for KSHV-positivity were estimated using Poisson regression. Results: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8% (95% CI: 7.9%-11.7%) in male migrants to 32.3% (95% CI: 24.1%-34.1%) in MSM. IVDU show intermediate level (17.5%, 95%CI: 14.1%-21.4%). KSHV was associated with syphilis (PR = 2.03, 95% CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95%: 1.22-2.75) but not in migrant workers or FSW. Conclusions: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10%, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals.

AB - Background: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. Methods: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China. KSHV-specific antibodies against latent and lytic antigens were assessed using Sf9 and BC3 monoclonal immunofluorescence assay. Age-adjusted prevalence ratios (PR) and 95% confidence interval (95% CI) for KSHV-positivity were estimated using Poisson regression. Results: In total, 4184 HIV-negative participants were included. KSHV prevalence ranged from 9.8% (95% CI: 7.9%-11.7%) in male migrants to 32.3% (95% CI: 24.1%-34.1%) in MSM. IVDU show intermediate level (17.5%, 95%CI: 14.1%-21.4%). KSHV was associated with syphilis (PR = 2.03, 95% CI: 1.38-2.98) in MSM but not in other groups. An association with human herpes virus 2 was also found among MSM (PR = 1. 83, 95%: 1.22-2.75) but not in migrant workers or FSW. Conclusions: KSHV prevalence in HIV-negative heterosexuals, FSW, and STI male patients from China is approximately 10%, but 2- and 3-fold higher in IVDU and MSM, respectively. Associations of KSHV with STIs among MSM only suggest that sexual transmission of the virus is important in MSM but not in heterosexuals.

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