Serologic determinants of survival in patients with head and neck cancer: Validating a clinical prediction model

Daniel D. Lydiatt, Howard E. Savage, Gary L. Clayman, Frank J. Liu, Dory Sample, Stimson P. Schantz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Quantitative measurements of serum Clq-binding macromolecules (ClqBM) and immunoglobulin A (IgA) were done on 162 patients using previously described methodology. The measurements were compared to a previously described head and neck cancer population. Using the Cox Proportional Hazards model, the prognostic implications regarding high ClqBM and subsequent death with disease (P = .02), and regional recurrence (P = .0094) were validated, but not our previous IgA-related prognostic implications. When both study populations were combined, ClqBM was predictive of survival in those patients treated with induction chemotherapy (P = .0001). ClqBM was not a significant predictor of survival in patients treated with surgery plus postoperative radiation therapy in either this second “test” population or in the original “training” population. The findings demonstrate the confounding influence of treatment modalities and the importance of model validation.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalLaryngoscope
Volume103
Issue number1
StatePublished - Jan 1993

Fingerprint

Head and Neck Neoplasms
Survival
Immunoglobulin A
Population
Induction Chemotherapy
Proportional Hazards Models
Radiotherapy
Recurrence
Serum
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Lydiatt, D. D., Savage, H. E., Clayman, G. L., Liu, F. J., Sample, D., & Schantz, S. P. (1993). Serologic determinants of survival in patients with head and neck cancer: Validating a clinical prediction model. Laryngoscope, 103(1), 13-16.

Serologic determinants of survival in patients with head and neck cancer : Validating a clinical prediction model. / Lydiatt, Daniel D.; Savage, Howard E.; Clayman, Gary L.; Liu, Frank J.; Sample, Dory; Schantz, Stimson P.

In: Laryngoscope, Vol. 103, No. 1, 01.1993, p. 13-16.

Research output: Contribution to journalArticle

Lydiatt, DD, Savage, HE, Clayman, GL, Liu, FJ, Sample, D & Schantz, SP 1993, 'Serologic determinants of survival in patients with head and neck cancer: Validating a clinical prediction model', Laryngoscope, vol. 103, no. 1, pp. 13-16.
Lydiatt DD, Savage HE, Clayman GL, Liu FJ, Sample D, Schantz SP. Serologic determinants of survival in patients with head and neck cancer: Validating a clinical prediction model. Laryngoscope. 1993 Jan;103(1):13-16.
Lydiatt, Daniel D. ; Savage, Howard E. ; Clayman, Gary L. ; Liu, Frank J. ; Sample, Dory ; Schantz, Stimson P. / Serologic determinants of survival in patients with head and neck cancer : Validating a clinical prediction model. In: Laryngoscope. 1993 ; Vol. 103, No. 1. pp. 13-16.
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