Serine/threonine phosphatases in the DNA damage response and cancer

Aimin Peng, J. L. Maller

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests that these kinases and their substrates are under tight modulation by numerous Ser/Thr phosphatases. In this study, we review recent reports that reveal new functions and regulation of these phosphatases. Similar to the kinases in this pathway, phosphatases may also be intimately involved in cancer progression and present valuable targets for cancer therapy.

Original languageEnglish (US)
Pages (from-to)5977-5988
Number of pages12
JournalOncogene
Volume29
Issue number45
DOIs
StatePublished - Nov 11 2010

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Phosphoprotein Phosphatases
Phosphoric Monoester Hydrolases
DNA Damage
Phosphotransferases
Neoplasms
Protein Kinases
Therapeutics

Keywords

  • DNA damage
  • cancer
  • checkpoint
  • protein phosphatase

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Serine/threonine phosphatases in the DNA damage response and cancer. / Peng, Aimin; Maller, J. L.

In: Oncogene, Vol. 29, No. 45, 11.11.2010, p. 5977-5988.

Research output: Contribution to journalReview article

Peng, Aimin ; Maller, J. L. / Serine/threonine phosphatases in the DNA damage response and cancer. In: Oncogene. 2010 ; Vol. 29, No. 45. pp. 5977-5988.
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