Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill

Hajime Tsujimoto, Akira Hasegawa, Noboru Maki, Masashi Fukasawa, Tomoyuki Miura, Stephan Speidel, Robert W. Cooper, Etsuko N. Moriyama, Takashi Gojobori, Masanori Hayami

Research output: Contribution to journalArticle

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Abstract

SINCE the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVSM), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.

Original languageEnglish (US)
Pages (from-to)539-541
Number of pages3
JournalNature
Volume341
Issue number6242
DOIs
StatePublished - Jan 1 1989

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Simian Immunodeficiency Virus
Mandrillus
HIV-2
Viruses
HIV-1
Cercocebus atys
Primate Lentiviruses
Cercopithecus aethiops
Lentivirus
Macaca
Haplorhini
Sequence Analysis
Acquired Immunodeficiency Syndrome
HIV

ASJC Scopus subject areas

  • General

Cite this

Tsujimoto, H., Hasegawa, A., Maki, N., Fukasawa, M., Miura, T., Speidel, S., ... Hayami, M. (1989). Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. Nature, 341(6242), 539-541. https://doi.org/10.1038/341539a0

Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. / Tsujimoto, Hajime; Hasegawa, Akira; Maki, Noboru; Fukasawa, Masashi; Miura, Tomoyuki; Speidel, Stephan; Cooper, Robert W.; Moriyama, Etsuko N.; Gojobori, Takashi; Hayami, Masanori.

In: Nature, Vol. 341, No. 6242, 01.01.1989, p. 539-541.

Research output: Contribution to journalArticle

Tsujimoto, H, Hasegawa, A, Maki, N, Fukasawa, M, Miura, T, Speidel, S, Cooper, RW, Moriyama, EN, Gojobori, T & Hayami, M 1989, 'Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill', Nature, vol. 341, no. 6242, pp. 539-541. https://doi.org/10.1038/341539a0
Tsujimoto H, Hasegawa A, Maki N, Fukasawa M, Miura T, Speidel S et al. Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. Nature. 1989 Jan 1;341(6242):539-541. https://doi.org/10.1038/341539a0
Tsujimoto, Hajime ; Hasegawa, Akira ; Maki, Noboru ; Fukasawa, Masashi ; Miura, Tomoyuki ; Speidel, Stephan ; Cooper, Robert W. ; Moriyama, Etsuko N. ; Gojobori, Takashi ; Hayami, Masanori. / Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill. In: Nature. 1989 ; Vol. 341, No. 6242. pp. 539-541.
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