31 Citations (Scopus)

Abstract

Approximately seventy patients undergo solid organ transplantation (SOT) every day in the United States. Sepsis remains the first or second most common cause of death in transplant recipients, depending on the allograft type. The rapid diagnosis and treatment of sepsis is critical to ensure improved survival outcome in this special patient population. However, these patients frequently lack the classic systemic inflammatory response syndrome (SIRS), commonly seen in the immunocompetent patients. In order to minimize delays in the diagnosis of sepsis in SOT recipients, it is paramount to recognize the specific risk factors for infection associated with each allograft type. In addition, the particular surgical techniques involved in each type of transplantation may be closely related to the clinical manifestations of the infection process. This correlation can further advance the diagnosis and treatment of sepsis. In conclusion, precocious diagnosis, rapid initiation of antibiotics, surgical correction when necessary, and reduction of immunosuppression, are the mainstream approach to sepsis in the SOT patient. The recent developments in severe sepsis are discussed in the context of the transplant recipient.

Original languageEnglish (US)
Pages (from-to)533-541
Number of pages9
JournalCurrent drug targets
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2007

Fingerprint

Transplantation (surgical)
Organ Transplantation
Sepsis
Transplants
Allografts
Systemic Inflammatory Response Syndrome
Anti-Bacterial Agents
Infection
Immunosuppression
Cause of Death
Transplantation
Survival
Therapeutics
Population

Keywords

  • Antibiotic
  • Cytomegalovirus
  • Immunosuppression
  • Pseudomonas aeruginosa
  • Systemic inflammatory response syndrome (SIRS)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Sepsis and solid organ transplantation. / Kalil, Andre C; Dakroub, H.; Freifeld, Alison Gail.

In: Current drug targets, Vol. 8, No. 4, 01.04.2007, p. 533-541.

Research output: Contribution to journalReview article

@article{3b298033eede456ab1e2c577013a8848,
title = "Sepsis and solid organ transplantation",
abstract = "Approximately seventy patients undergo solid organ transplantation (SOT) every day in the United States. Sepsis remains the first or second most common cause of death in transplant recipients, depending on the allograft type. The rapid diagnosis and treatment of sepsis is critical to ensure improved survival outcome in this special patient population. However, these patients frequently lack the classic systemic inflammatory response syndrome (SIRS), commonly seen in the immunocompetent patients. In order to minimize delays in the diagnosis of sepsis in SOT recipients, it is paramount to recognize the specific risk factors for infection associated with each allograft type. In addition, the particular surgical techniques involved in each type of transplantation may be closely related to the clinical manifestations of the infection process. This correlation can further advance the diagnosis and treatment of sepsis. In conclusion, precocious diagnosis, rapid initiation of antibiotics, surgical correction when necessary, and reduction of immunosuppression, are the mainstream approach to sepsis in the SOT patient. The recent developments in severe sepsis are discussed in the context of the transplant recipient.",
keywords = "Antibiotic, Cytomegalovirus, Immunosuppression, Pseudomonas aeruginosa, Systemic inflammatory response syndrome (SIRS)",
author = "Kalil, {Andre C} and H. Dakroub and Freifeld, {Alison Gail}",
year = "2007",
month = "4",
day = "1",
doi = "10.2174/138945007780362746",
language = "English (US)",
volume = "8",
pages = "533--541",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Sepsis and solid organ transplantation

AU - Kalil, Andre C

AU - Dakroub, H.

AU - Freifeld, Alison Gail

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Approximately seventy patients undergo solid organ transplantation (SOT) every day in the United States. Sepsis remains the first or second most common cause of death in transplant recipients, depending on the allograft type. The rapid diagnosis and treatment of sepsis is critical to ensure improved survival outcome in this special patient population. However, these patients frequently lack the classic systemic inflammatory response syndrome (SIRS), commonly seen in the immunocompetent patients. In order to minimize delays in the diagnosis of sepsis in SOT recipients, it is paramount to recognize the specific risk factors for infection associated with each allograft type. In addition, the particular surgical techniques involved in each type of transplantation may be closely related to the clinical manifestations of the infection process. This correlation can further advance the diagnosis and treatment of sepsis. In conclusion, precocious diagnosis, rapid initiation of antibiotics, surgical correction when necessary, and reduction of immunosuppression, are the mainstream approach to sepsis in the SOT patient. The recent developments in severe sepsis are discussed in the context of the transplant recipient.

AB - Approximately seventy patients undergo solid organ transplantation (SOT) every day in the United States. Sepsis remains the first or second most common cause of death in transplant recipients, depending on the allograft type. The rapid diagnosis and treatment of sepsis is critical to ensure improved survival outcome in this special patient population. However, these patients frequently lack the classic systemic inflammatory response syndrome (SIRS), commonly seen in the immunocompetent patients. In order to minimize delays in the diagnosis of sepsis in SOT recipients, it is paramount to recognize the specific risk factors for infection associated with each allograft type. In addition, the particular surgical techniques involved in each type of transplantation may be closely related to the clinical manifestations of the infection process. This correlation can further advance the diagnosis and treatment of sepsis. In conclusion, precocious diagnosis, rapid initiation of antibiotics, surgical correction when necessary, and reduction of immunosuppression, are the mainstream approach to sepsis in the SOT patient. The recent developments in severe sepsis are discussed in the context of the transplant recipient.

KW - Antibiotic

KW - Cytomegalovirus

KW - Immunosuppression

KW - Pseudomonas aeruginosa

KW - Systemic inflammatory response syndrome (SIRS)

UR - http://www.scopus.com/inward/record.url?scp=34247596363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247596363&partnerID=8YFLogxK

U2 - 10.2174/138945007780362746

DO - 10.2174/138945007780362746

M3 - Review article

C2 - 17430124

AN - SCOPUS:34247596363

VL - 8

SP - 533

EP - 541

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 4

ER -