Sensitization of c-fos expression in rat striatum following multiple challenges with d-amphetamine

Andrew B. Norman, Sunny Y. Lu, Jennifer M. Klug, Robert B. Norgren

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d-Amphetamine transiently stimulates the expression of the immediate-early response gene, c-fos, in rat striatal cell nuclei. d-Amphetamine (2.5 mg/kg i.p.) induced a significantly greater expression of Fos-like immunoreactivity in striatum of rats treated three days previously with d-amphetamine compared to rats treated three days previously with saline. This increase in the expression of Fos-like immunoreactivity in rat striatum was characterized by a significantly greater number of immunoreactive nuclei and a significant increase in the intensity of the immunoreactivity. This sensitization of c-fos expression following a repeated administration of d-amphetamine indicates an increased activation of post-synaptic elements in rat striatum.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Feb 12 1993



  • Addiction
  • Cell counting
  • Immediate-early response gene
  • Immunocytochemistry
  • Oncoprotein
  • Stimulant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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